血管内介入栓塞术对隐匿性脑血管畸形出血患者VEGF、LP、Ang1、Ang2的影响  

Effect of Endovascular Interventional Embolization on VEGF,LP,Ang1,Ang2 in Patients with OccultCerebral Vascular Malformation Hemorrhage

作　　者：唐明君 TANG Mingjun(Guizhou Guihang Guiyang Hospital,Guiyang 550009,China)

机构地区：[1]贵州省贵航贵阳医院,贵州贵阳550009

出　　处：《航空航天医学杂志》2023年第8期897-900,共4页Journal of Aerospace medicine

摘　　要：目的 分析血管内介入栓塞手术用于隐匿性脑血管畸形(OVMS)出血对患者瘦素(LP)、血管内皮生长因子(VEGF)、血管生成素1(Ang1)及血管生成素2(Ang2)的影响。方法 于2021年01月-2022年10月收入OVMS出血患者总共98例,经随机数字表法将其分成对照组(常规切除畸形血管并清除颅内血肿)、观察组(血管内介入栓塞手术)各有49例,比较两组疗效;生活能力分级;并发症;术前术后LP、VEGF、Ang1、Ang2含量;术前术后颈内动脉、颈总动脉以及椎动脉血流速度。结果 观察组在有效率方面是95.92%远远高于对照组79.59%(P<0.05)。观察组在生活能力分级方面远远优于对照组(P<0.05)。观察组在并发症占比方面是4.08%远远低于对照组18.37%(P<0.05)。术前,两组LP、VEGF、Ang1、Ang2含量相比无差异(P>0.05);术后,两组LP、VEGF、Ang2均较术前降低(P<0.05),Ang1含量均较术前升高(P<0.05),且观察组LP、VEGF、Ang2含量低于对照组(P<0.05),Ang1含量高于对照组(P<0.05)。术前,两组颈内动脉、颈总动脉以及椎动脉的血流速度相比无差异(P>0.05);术后,两组颈内动脉、颈总动脉以及椎动脉的血流速度均较前提升(P<0.05),且观察组颈内动脉、颈总动脉以及椎动脉的血流速度高于对照组(P<0.05)。结论 血管内介入栓塞手术用于OVMS出血患者疗效理想,能提升生活能力,减少并发症出现,改善LP、VEGF、Ang1以及Ang2水平,促进脑血管血流恢复,值得采用。Objective To analyze the effects of endovascular interventional embolization on leptin(LP),vascular endothelial growth factor(VEGF),Ang1 and Ang2 in patients with occulted cerebrovascular malformations(OVMS).Methods A total of 98 patients with OVMS hemorrhage were enrolled from January 2021 to October 2022.They were divided into control group(routine resection of malformed blood vessels and removal of intracranial hematoma)and observation group(endovascular interventional embolization)with 49 cases each by random number table method.The efficacy of the two groups was compared.Life ability rating;Complications;The contents of LP,VEGF,Ang1 and Ang2 before and after operation;Blood flow velocity of internal carotid artery,common carotid artery and vertebral artery before and after operation.Results The effective rate of observation group was 95.92%,which was much higher than that of control group 79.59%(P<0.05).The observation group was much better than the control group in life ability classification(P<0.05).The proportion of complications in the observation group was 4.08%,much lower than that in the control group 18.37%(P<0.05).Before operation,there were no differences in LP,VEGF,Ang1 and Ang2 contents between the two groups(P>0.05).After surgery,LP,VEGF and Ang2 in both groups were decreased compared with those before surgery(P<0.05),and Ang1 content was increased compared with those before surgery(P<0.05),and the contents of LP,VEGF and Ang2 in observation group were lower than those in control group(P<0.05),and Ang1 content was higher than that in control group(P<0.05).Before operation,there was no difference in blood flow velocity of internal carotid artery,common carotid artery and vertebral artery between two groups(P>0.05).After operation,the blood flow velocity of internal carotid artery,common carotid artery and vertebral artery was increased in both groups(P<0.05),and the blood flow velocity of internal carotid artery,common carotid artery and vertebral artery in observation group was higher than that

关 键 词：隐匿性脑血管畸形 血管内介入栓塞术 瘦素 血管内皮生长因子 血管生成素1 血管生成素2 

分 类 号：R743.4[医药卫生—神经病学与精神病学]