乳腺癌改良根治术与乳腺区段切除联合腋窝淋巴结清扫术治疗早期乳腺癌患者的临床疗效  

Clinical efficacy of modified radical mastectomy and partial mastectomy combined with axillary lymph node dissection in the treatment of early breast cancer patients

作　　者：户庄[1] 周振宇[1] 李文龙 HU Zhuang;ZHOU Zhenyu;LI Wenlong(Department of Thyroid and Mammary Glands,Huaihe Hospital of He’nan University,Kaifeng 475000,He’nan,China)

机构地区：[1]河南大学淮河医院甲状腺乳腺科,河南开封475000

出　　处：《癌症进展》2023年第16期1847-1850,共4页Oncology Progress

摘　　要：目的探讨乳腺癌改良根治术与乳腺区段切除(PM)联合腋窝淋巴结清扫术(ALND)治疗早期乳腺癌患者的临床疗效。方法根据治疗方式的不同将106例乳腺癌患者分为对照组(n=57)和观察组(n=49),对照组患者采用乳腺癌改良根治术,观察组患者采用PM+ALND。比较两组患者的临床疗效、肿瘤标志物[血清铁蛋白(SF)、降钙素原(PCT)、癌胚抗原(CEA)及糖类抗原153(CA153)]水平、乳房美容效果及预后。结果观察组患者的疾病控制率为95.92%,与对照组患者的98.25%比较,差异无统计学意义(P﹥0.05)。术前和术后1个月,两组患者的PCT、SF、CEA、CA153水平比较,差异均无统计学意义(P﹥0.05);术后1个月,两组患者的PCT、SF、CEA、CA153水平均低于本组术前,差异均有统计学意义(P﹤0.05)。观察组患者的乳房美容优良率为87.76%,高于对照组患者的71.93%,差异有统计学意义(P﹤0.05)。术后1年,两组患者的生存率、复发率、转移率比较,差异均无统计学意义(P﹥0.05)。结论乳腺癌改良根治术与PM+ALND治疗早期乳腺癌患者的临床疗效相当,均能够较好地控制疾病进展,获得较高的生存率,但PM+ALND在保持患者乳房美观度方面效果更佳。Objective To investigate the clinical efficacy of modified radical mastectomy and partial mastectomy(PM)combined with axillary lymph node dissection(ALND)in the treatment of early breast cancer patients.Method A total of 106 patients with breast cancer were divided into the control group(n=57,treated with modified radical mastectomy)and observation group(n=49,treated with PM+ALND)according to different treatment methods.The clinical efficacy,tumor markers[serum ferritin(SF),procalcitonin(PCT),carcinoembryonic antigen(CEA)and carbohydrate antigen 153(CA153)]levels,breast cosmetic effect and prognosis were compared between the two groups.Result There was no significant difference in the disease control rate between the observation group and the control group(95.92%vs 98.25%,P>0.05).There were no significant differences in the levels of PCT,SF,CEA and CA153 between the two groups before and one month after surgery(P>0.05).One month after surgery,the levels of PCT,SF,CEA and CA153 in the two groups were lower than those before surgery,the differences were statistically significant(P<0.05).The excellent and good rate of breast cosmetic in the observation group was higher than that in the control group(87.76%vs 71.93%,P<0.05).There were no significant differences in survival rate,recurrence rate and metastasis rate one year after surgery between the two groups(P>0.05).Conclusion In the treatment of patients with early breast cancer,the efficacy of radical mastectomy and PM+ALND is comparable,both methods can effectively control the disease progression and achieve higher survival rate,but PM+ALND has better breast cosmetic effect.

关 键 词：乳腺癌 乳腺癌根治术 乳腺区段切除术 腋窝淋巴结清扫术 生存率 

分 类 号：R737.9[医药卫生—肿瘤]