Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation ofα-dehydro amino ketones  

作　　者：Xuefeng Tan Shuang Gao Chunyan Yang Qiwei Lang Xiaobing Ding Gen-Qiang Chen Xumu Zhang 

机构地区：[1]Laboratory of Small Molecule Drug Discovery and Synthesis,Department of Chemistry,Southern University of Science and Technology,Shenzhen 518055,China [2]Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen 518000,China [3]Department of Chemistry,City University of Hong Kong,Hong Kong 999077,China

出　　处：《Science China Chemistry》2023年第10期2847-2851,共5页中国科学（化学英文版）

基　　金：the National Key R&D Program of China(2021YFA1500201);the Stable Support Plan Program of Shenzhen Natural Science Fund(20200925161222002);the Key-Area Research and Development Program of Guangdong Province(2020B010188001);the Innovative Team of Universities in Guangdong Province(2020KCXTD016);the National Natural Science Foundation of China(21991113);the Guangdong Basic and Applied Basic Research Foundation(2022B1515020055);the National Natural Science Foundation of China(22171129);Shenzhen Science and Technology Innovation Committee(JCYJ20210324104202007)for financial support。

摘　　要：A series of novel atropisomeric diphosphine ligands termed Tan Phos were designed and synthesized,which has a smaller bite angle compared with that of other ligands such as BINAP.Tan Phos showed high reactivity and enantioselectivity in the rhodiumcatalyzed asymmetric hydrogenation ofα-dehydro amino ketones,and up 99%yield and 99%ee were obtained for a wide range of chiralα-amino ketones.

关 键 词：DIPHOSPHINE asymmetric hydrogenation chiral ligand 

分 类 号：O641.4[理学—物理化学]