Cu/photoredox-catalyzed decarboxylative radical C(sp^(3))–C(sp^(3))cross-coupling reactions  

作　　者：Chao Jiang Pinhong Chen Guosheng Liu 

机构地区：[1]State Key Laboratory of Organometallic Chemistry and Shanghai Hongkong Joint Laboratory in Chemical Synthesis,Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Science China Chemistry》2023年第10期2858-2862,共5页中国科学（化学英文版）

基　　金：supported by the National Key R&D Program of China(2021YFA1500100);the National Natural Science Foundation of China(91956202,92256301,21821002,21971255);the Science and Technology Commission of Shanghai Municipality(20JC1417000,21520780100);the International Partnership Program(121731KYSB20190016)of the Chinese Academy of Sciences。

摘　　要：A radical decarboxylative C(sp^(3))–C(sp^(3))cross-coupling of NHPI esters and cyclopropanols was developed by combining photocatalysis and copper catalysis,which presents the efficient access toβ-benzyl ketones in excellent yields.Terpyridin-4′-one used as the ligand is vital for the reaction,which could facilitate the capture of benzylic radicals by alkyl-copper species generated from copper-catalyzed ring-opening of cyclopropanols.The reaction exhibited broad substrate scope and wide functional group compatibility,providing an alternative approach for C(sp^(3))–C(sp^(3))bond formation.

关 键 词：copper catalysis C(sp^(3))-C(sp^(3))cross-coupling PHOTOREDOX NHPI ester cyclopropanol 

分 类 号：O621.251[理学—有机化学]