颞下颌关节骨关节炎发病机制研究进展  

Research progress on the pathogenesis and risk factors of temporomandibular joint osteoarthritis

作　　者：常攀辉[1] 冯㛃 张智玲[2] 葛化冰[1] 黎凯歌 CHANG Pan-hui;FENG Jie;ZHANG Zhi-ling;GE Hua-bing;LI Kai-ge(Department of General Dentistry,Capital Medical University School of Stomatology,Beijing 100006,China)

机构地区：[1]首都医科大学附属北京口腔医院王府井综合科,100006 [2]天津市口腔医院,300041

出　　处：《中华老年口腔医学杂志》2023年第4期242-246,共5页Chinese Journal of Geriatric Dentistry

基　　金：天津市自然科学基金多元投入面上项目(21JCYBJC01340)。

摘　　要：颞下颌关节骨关节炎(temporomandibular joint osteoarthritis,TMJOA)为关节退行性病变,患者常表现为剧烈疼痛、关节功能障碍。以进行性软骨退化、软骨下骨重塑等为主要病理特征,现阶段关于颞下颌关节骨关节炎的确切发病机制并不十分明确,相关研究文献结论尚未统一,多数学者认为TMJOA患者为多种致病因素共同作用后发病,机制较复杂。多因素致病模式通常是几个因素共同作用的结果,某一个体是否发病,可能与致病因素的多少和强弱有关。与身体其他关节相比,颞下颌关节具有其特殊性,本文将近十年内关于颞下颌关节骨性关节炎发病机制及危险因素的研究进展作一综述。Temporomandibular joint osteoarthritis(TMJOA)is a degenerative joint disease in which presents open with severe pain and joint dysfunction.The main pathological features of temporomandibular joint osteoarthritis are progressive cartilage degeneration and subchondral bone remodeling.At present,the exact pathogenesis of temporomandibular joint osteoarthritis is not very clear,and the conclusions of relevant research literature have not been unified.Most scholars believe that TMJOA patients develop after the combined use of multiple pathogenic factors,and the mechanism is relatively complex.The multifactorial pathogenic pattern is usually the result of several factors working together,whether an individual is affected may be related to the number and strength of the pathogenic factors.Compared with other joints in the body,the temporomandibular joint has its unique characteristics.This paper reviews the latest research progress on the pathogenesis and risk factors of temporomandibular joint osteoarthritis in the past decade.

关 键 词：颞下颌关节骨关节炎 危险因素 发病机制 

分 类 号：R782[医药卫生—口腔医学]