中西医结合治疗乳腺癌化疗后呕吐的疗效meta分析  

Meta-analysis of Curative Effect of Integrated Traditional Chinese and Western Medicine in the Treatment of Vomiting After Chemotherapy for Breast Cancer

作　　者：彭火平 余腾骅 孙正魁[1] PENG Huoping;YU Tenghua;SUN Zhengkui(Jiangxi Cancer Hospital,Nanchang,330029)

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2023年第10期1584-1589,共6页The Practical Journal of Cancer

基　　金：国家自然科学基金(编号:81260329,82160565);江西省自然科学基金(编号:202112BAB216063)。

摘　　要：目的评价中西医结合治疗乳腺癌化疗后呕吐的疗效,为中医药治疗乳腺癌化疗后呕吐提供进一步的循证医学证据,与西药疗效优势互补。方法通过检索国内数据库如:中国知网数据库(CNKI)、维普数据库(VIP)、万方数据库(Wan Fang Data)、中国生物医学数据库(CBM)及国外数据库如:PubMed数据库、Cochrane Library和Embase数据库查找关于中西医结合治疗乳腺癌化疗后呕吐的临床随机对照实验。按照纳入标准和排除标准筛选相关文献,对纳入文献运用Cochrane风险偏倚评估工具和Revman5.3软件进行文献质量评价,同时对结局指标有效率进行meta分析。结果最终纳入10篇临床随机对照实验,共702人。Meta分析结果显示中西医结合治疗在改善乳腺癌化疗后急性期呕吐(RR=1.73,95%CI[1.49,2.00],Z=7.22,P<0.00001)及延迟期呕吐(RR=1.37,95%CI[1.06~1.77],Z=2.38,P=0.02)方面明显高于单纯西医组。结论中西医结合治疗在改善乳腺癌患者化疗所致呕吐方面有一定疗效,但由于其数据质量等级的局限性,今后仍需高质量研究的临床证据来证明。Objective To evaluate the effect of traditional Chinese and western medicine for vomiting after chemotherapy for breast cancer,provide further evidence for evidence-based medicine,and fill the blank for western medicine.Methods Relevant databases such as China National Knowledge Infrastructure(CNKI),VIP database(VIP),Wan Fang Data(Wan Fang Data),China Biology Medicine Database(CBM),PubMed,the Cochrane Library and Embase database were searched to find the clinical randomized controlled trials of integrated Chinese and Western medicine in the treatment of vomiting after chemotherapy for breast cancer.Relevant literature was screened according to inclusion criteria and exclusion criteria to determine the included literature.Cochrane risk bias assessment tool and Revman5.3 software were used to evaluate the literature quality.Meta-analysis was conducted on the effectiveness of outcome indicators.Results 702 patients were included in 10 randomized controlled trials.Meta-analysis showed that experimental group improved acute phase vomiting after breast cancer chemotherapy(RR=1.73,95%CI[1.49,2.00].Z=7.22,P<0.00001)and delayed vomiting(RR=1.37,95%CI[1.06~1.77],Z=2.38,P=0.02)were significantly higher than those in the control group.Conclusion Experimental group has a certain effect on improving vomiting after chemotherapy in breast cancer patients.However,due to the quality of the limited data.It is necessary to obtain more clinical evidence from high-quality studies in the future.

关 键 词：中西医结合 乳腺癌 化疗 呕吐 META分析 

分 类 号：R737.9[医药卫生—肿瘤]