喉部分切除术与喉部全切术对喉癌患者生存质量及预后的影响分析  

Effect of Partial Laryngectomy and Total Laryngeal Resection on the Quality of Survival and Prognosis of Laryngeal Cancer Patients

作　　者：丁永丽[1] 李小静 王少英[1] DING Yongli;LI Xiaojing;WANG Shaoying(Henan People's Hospital,Zhengzhou,450000)

机构地区：[1]河南省人民医院,450000

出　　处：《实用癌症杂志》2023年第10期1600-1603,共4页The Practical Journal of Cancer

摘　　要：目的探讨喉部分切除术与喉部全切术对喉癌的临床效果及安全性。方法选取80例喉癌患者,按随机数字表法分为两组,各40例。对照组予以喉部全切术治疗,观察组予以喉部分切除术治疗,术后随访1年。比较两组吞咽功能恢复情况、手术情况、疼痛评分、血清炎症因子水平、生存质量、预后情况及并发症。结果观察组吞咽功能恢复优良率较对照组高,术后喉黏膜水肿时间[(8.69±1.12)d]、住院时间[(9.54±1.18)d]短于对照组,有统计学差异(P<0.05);观察组术后1 d、3 d及7 d时视觉模拟评分[(5.82±1.09)分、(3.56±0.52)分、(2.04±0.35)分]低于对照组,有统计学差异(P<0.05);观察组术后C反应蛋白(CRP)[(9.95±1.24)mg/L]、白介素-6(IL-6)水平[(7.89±1.14)ng/L]低于对照组,有统计学差异(P<0.05);观察组术后生活质量中生理领域[(84.76±7.29)分]、心理领域[(87.58±7.14)分]、社会领域[(88.31±8.25)分]及环境领域[(89.65±7.29)分]评分高于对照组,有统计学差异(P<0.05);两组肿瘤复发率相比,无统计学差异(P>0.05);观察组并发症发生率低于对照组,有统计学差异(P<0.05)。结论喉部分切除术治疗喉癌效果更佳,能减轻机体创伤及术后疼痛,加快吞咽功能恢复,提高术后生存质量,且并发症少,不会增加肿瘤复发风险。Objective To investigate the clinical effect and safety of partial laryngectomy and total laryngectomy in the treatment of laryngeal cancer.Methods 80 patients with laryngeal cancer treated were randomly divided into 2 groups with 40 cases in each group.The control group was treated with total laryngectomy,and the observation group was treated with partial laryngectomy.The patients were followed up for 1 year.The recovery of swallowing function,surgery,pain score,serum inflammatory factor level,quality of life,prognosis and complications were compared between the two groups.Results The excellent and good rate of swallowing function recovery in the observation group was higher than that in the control group.The postoperative laryngeal mucosal edema time[(8.69±1.12)D]and hospital stay[(9.54±1.18)D]were shorter than those in the control group,with statistical differences(P<0.05);The visual analogue scale(VAS)score[(5.82±1.09),(3.56±0.52),(2.04±0.35)]of the observation group at 1D,3D and 7d after operation was lower than that of the control group,with statistical difference(P<0.05);The levels of C-reactive protein(CRP)[(9.95±1.24)mg/l]and interleukin-6(IL-6)[(7.89±1.14)ng/l]in the observation group were lower than those in the control group,with statistical difference(P<0.05);The scores of physiological field[(84.76±7.29)points],psychological field[(87.58±7.14)points],social field[(88.31±8.25)points]and environmental field[(89.65±7.29)points]in the observation group were significantly higher than those in the control group(P<0.05);There was no significant difference in the recurrence rate between the 2 groups(P>0.05);The complications in the observation group were less than those in the control group,with statistical difference(P<0.05).Conclusion Partial laryngectomy is more effective in the treatment of laryngeal cancer,which can reduce body trauma and postoperative pain,speed up the recovery of swallowing function,improve postoperative quality of life,and has fewer complications,and will not increase the

关 键 词：喉癌 喉部分切除术 喉部全切术 生存质量 并发症 临床预后 

分 类 号：R739.65[医药卫生—肿瘤]