超声联合血清VEGF、TSGF水平检测对分化型甲状腺癌的诊断价值  

Diagnostic Value of Ultrasonography Combined with Serum VEGF and TSGF Levels in Differentiated Thyroid Carcinoma

作　　者：刘敏 原媛 李岩[1] LIU Min;YUAN Yuan;LI Yan(Xinxiang Central Hospital,Xinxiang,453000)

机构地区：[1]河南省新乡市中心医院,453000

出　　处：《实用癌症杂志》2023年第10期1612-1616,共5页The Practical Journal of Cancer

摘　　要：目的探讨超声联合血清VEGF、TSGF水平检测对分化型甲状腺癌的诊断价值及与其临床病理特征的关系。方法将分化型甲状腺癌患者70例纳入观察组,再将同时期收集的甲状腺结节患者60例纳入对照组。分化型甲状腺癌依据腺癌类型不同进行分组,即甲状腺乳头状癌组(PTC组)(n=50)、甲状腺滤泡状癌组(FTC组)(n=20)。比较观察组与对照组、PTC组与FTC组超声检查结果及血清VEGF、TSGF水平,分析血清VEGF、TSGF水平与分化型甲状腺癌临床病理特征的关系。结果观察组与对照组在病灶边界、形态、内部结构、回声、钙化、甲状腺周围淋巴结肿大、血清VEGF、TSGF水平方面比较,P<0.05,两组在血流方面比较,P>0.05。PTC组、FTC组在血流、甲状腺周围淋巴结肿大、血清VEGF、TSGF水平方面比较,P<0.05,在病灶边界、形态、回声、钙化方面比较,P>0.05。血清VEGF、TSGF水平与分化型甲状腺癌肿瘤大小、淋巴结转移有关,P<0.05,与性别、年龄、TNM分期无关,P>0.05。超声联合血清VEGF、TSGF水平检测对分化型甲状腺癌的诊断灵敏度(98.31%)显著高于单纯超声检查(86.05%),P<0.05,超声联合血清VEGF、TSGF水平检测的特异度、阳性预测值、阴性预测值均略高于超声检查。结论血清VEGF、TSGF水平与分化型甲状腺癌患者肿瘤侵袭、转移存在关系,且超声联合血清VEGF、TSGF水平诊断价值更高。Objective To investigate the diagnostic value of ultrasonography combined with serum VEGF and TSGF levels in differentiated thyroid carcinoma and its relationship with clinicopathologic features.Methods 70 patients with differentiated thyroid carcinoma were included in the observation group,and 60 patients with thyroid nodules were included in the control group.Differentiated thyroid carcinoma was divided into different groups according to the type of adenocarcinoma,namely papillary thyroid carcinoma group(PTC group)(n=50)and follicular thyroid carcinoma group(FTC group)(n=20).The ultrasonographic results and serum levels of VEGF and TSGF were compared between the observation group and the control group,PTC group and FTC group,and the relationship between serum levels of VEGF and TSGF and clinicopathologic features of differentiated thyroid carcinoma was analyzed.Results The comparison of lesion boundary,morphology,internal structure,echo,calcification,peripheral thyroid lymph node enlargement,serum VEGF and TSGF levels between the observation group and the control group,P<0.05,and the comparison of blood flow between the 2 groups,P>0.05.PTC group and FTC group were compared in blood flow,peripheral thyroid lymph node enlargement,serum VEGF,TSGF levels,P<0.05,and lesion boundary,morphology,echo,calcification,P>0.05.Serum VEGF and TSGF levels were correlated with tumor size and lymph node metastasis of differentiated thyroid cancer(P<0.05),but not with gender,age or TNM stage(P>0.05).The diagnostic sensitivity of ultrasonography combined with serum VEGF and TSGF levels for differentiated thyroid cancer(98.31%)was significantly higher than that of ultrasonography alone(86.05%),P<0.05,and the specificity,positive predictive value and negative predictive value of ultrasonography combined with serum VEGF and TSGF levels were slightly higher than ultrasonography.Conclusion Serum VEGF and TSGF levels are related to tumor invasion and metastasis in patients with differentiated thyroid cancer,and ultrasound combined with

关 键 词：分化型甲状腺癌 超声检查 VEGF TSGF 诊断价值 

分 类 号：R736.1[医药卫生—肿瘤]