丁苯酞序贯治疗急性进展性脑梗死患者对其神经功能与炎症因子及同型半胱氨酸和特异性烯醇化酶的影响  

Effects of butylphthalide sequential treatment on neurological function,inflammatory factors,homocysteine and neuron specific enolase in patients with acute progressive cerebral infarction

作　　者：许亚楠 XU Ya'nan(Department of Neurology,Lingyuan Hospital of Traditional Chinese Medicine,Chaoyang,Liaoning,122500,China)

机构地区：[1]辽宁省凌源市中医院神经内科,辽宁朝阳122500

出　　处：《当代医学》2023年第14期90-93,共4页Contemporary Medicine

摘　　要：目的探究丁苯酞序贯治疗急性进展性脑梗死患者对其神经功能、炎症因子、同型半胱氨酸(Hcy)、特异性烯醇化酶(NSE)的影响。方法选取2018年2月至2020年2月本院收治100例急性进展性脑梗死患者作为研究对象,随机分为实验组与对照组,各50例。对照组采用常规治疗,实验组在对照组基础上联合丁苯酞序贯治疗,比较两组神经功能及白细胞介素6(IL-6)、Hcy、NSE水平。结果两组美国国立卫生研究院卒中量表(NIHSS)评分及IL-6、Hcy、NSE水平组间、时间、交互比较差异有统计学意义(P<0.05)。组内比较:两组治疗后各时间点NIHSS评分及IL-6、Hcy、NSE水平均低于前一时间点,差异有统计学意义(P<0.05)。组间比较:治疗前,两组NIHSS评分及IL-6、Hcy、NSE水平比较差异无统计学意义;治疗14、40 d,实验组NIHSS评分及IL-6、Hcy、NSE水平均低于对照组,差异有统计学意义(P<0.05)。结论丁苯酞序贯治疗急性进展性脑梗死患者可有效恢复其神经功能,减轻炎症反应,降低Hcy、NSE水平,值得临床推广应用。Objective To investigate the effects of butylphthalide sequential treatment on neurological function,inflammatory factors,homocysteine(Hcy),and neuron specific enolase(NSE)in patients with acute progressive cerebral infarction.Methods 100 patients with acute progressive cerebral infarction admitted to our hospital from February 2018 to February 2020 were selected as the study subjects,and they were randomly divided into the experimental group and the control group,with 50 cases in each group.The control group was treated with routine treatment,and the experimental group was treated with butylphthalide sequential treatment on the basis of the control group,the neurological function and levels of interleukin6(IL-6),Hcy and NSE were compared between the two groups.Results There were significant differences of the National Institutes of health stroke scale(NIHSS)and IL-6,Hcy and NSE levels between two groups of group,time points and interaction(P<0.05).Comparison within the group:the NIHSS score and the IL-6,Hcy and NSE levels at each time point after treatment of the two groups were lower than the previous time point,and the differences were statistically significant(P<0.05).Comparison between groups:before treatment,there were no significant differences in NIHSS score and IL-6,Hcy and NSE levels between the two groups;after 14 and 40 d of treatment,NIHSS score and IL-6,Hcy and NSE levels in the experimental group were lower than the control group,and the differences were statistically significant(P<0.05).Conclusion Butylphthalide sequential treatment in patients with acute progressive cerebral infarction can effectively restore their neurological function,reduce inflammatory response,and reduce the levels of Hcy and NSE,which is worthy of clinical promotion and application.

关 键 词：丁苯酞序贯治疗 急性进展性脑梗死 同型半胱氨酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]