化学发光免疫法在肿瘤生物标志物检验中的应用价值  

Application value of chemiluminescence immunoassay in the detection of tumor biomarkers

作　　者：栗岩 刘小莲 LI Yan;LIU Xiaolian(Department of Laboratory,Hezhou Guangji Hospital,Hezhou,Guangxi,542800,China)

机构地区：[1]贺州广济医院检验科,广西贺州542800

出　　处：《当代医学》2023年第14期115-117,共3页Contemporary Medicine

摘　　要：目的探讨化学发光免疫法在肿瘤生物标志物检验中的应用价值。方法选取2017年6月至2020年8月于本院接受诊治的42例原发性肿瘤患者作为观察组,另选取同期45名健康体检者作为对照组。两组均采用化学发光免疫法检测肿瘤生物标志物,比较两组癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、甲胎蛋白(AFP)、糖类抗原153(CA153)水平及阳性检出率。结果观察组CEA、CA125、CA19-9、AFP及CA153水平均高于对照组,差异有统计学意义(P<0.05)。观察组CEA、CA125、CA19-9及CA153阳性检出率均高于对照组,差异有统计学意义(P<0.05);两组AFP阳性检出率比较差异无统计学意义。结论化学发光免疫法应用于肿瘤生物标志物检测效果显著,灵敏度、准确度较高,可为疾病诊断、病情评估提供临床依据。Objective To explore the application value of chemiluminescence immunoassay in the detection of tumor biomarkers.Methods 42 patients with primary tumors who received treatment in our hospital from June 2017 to August 2020 were selected as the observation group,and 45 healthy subjects during the same period were selected as the control group.Tumor biomarkers were detected by chemiluminescence immunoassay in both groups,and the levels and positive detection rates of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9),alpha fetoprotein(AFP),and carbohydrate antigen 153(CA153)were compared between the two groups.Results The levels of CEA,CA125,CA19-9,AFP,and CA153 in the observation group were higher than the control group,and the differences were statistically significant(P<0.05).The positive detection rates of CEA,CA125,CA19-9,and CA153 in the observation group were higher than the control group,and the differences were statistically significant(P<0.05);there was no significant difference in the positive detection rate of AFP between the two groups.Conclusion Chemiluminescent immunoassay is effective in tumor biomarker testing,with high sensitivity and accuracy,it can provide clinical evidence for disease diagnosis and assessment.

关 键 词：肿瘤生物标志物 临床检验 化学发光免疫法 应用效果 

分 类 号：R730.51[医药卫生—肿瘤]