全胸腔镜肺叶切除术对非小细胞肺癌患者应激反应和炎症反应影响  

Effects of total thoracoscopic lobectomy on stress and inflammation in patients with non-small cell lung cancer

作　　者：王坤 赵敬国 王善良 WANG Kun;ZHAO Jingguo;WANG Shanliang(Qingdao Jiaozhou Central Hospital,Qingdao,Shandong 266300,China)

机构地区：[1]青岛市胶州中心医院,山东青岛266300

出　　处：《临床肺科杂志》2023年第11期1728-1731,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的 分析全胸腔镜肺叶切除术对非小细胞肺癌(non small-cell lung cancer,NSCLC)患者应激反应和炎症反应的影响。方法 选择2020年6月至2022年12月我院收治的155例NSCLC患者开展回顾性研究,根据手术方式的不同分为对照组(传统肺叶切除术,n=75)和观察组(全胸腔镜肺叶切除术,n=80),比较两组围术期指标,应激反应指标:促肾上腺皮质激素(adreno-cortico-tropic-hormone,ACTH)、生长激素、皮质醇及P物质,白细胞介素6(interleukin-6,IL-6)、白细胞介素-12(interleukin-12,IL-12)、干扰素-γ(interferon-γ,IFN-γ)水平等。结果 观察组手术时间、术中出血量、术后引流量情况均优于对照组(P<0.05),两组淋巴结清扫数目对比无统计学差异(P>0.05);观察组ACTH、生长激素、皮质醇和P物质水平均低于对照组(P<0.05);观察组IL-6、IL-12、IFN-γ水平均低于对照组(P<0.05);观察组术后用力肺活量和呼气峰值流速高于对照组(P<0.05)。结论 全胸腔镜肺叶切除术应用在非小细胞肺癌患者的治疗中,可降低患者手术创伤和应激反应,改善患者炎症反应和呼吸功能,促进术后康复。Objective To analyze the effect of total thoracoscopic lobectomy on stress and inflammation in patients with non-small cell lung cancer(NSCLC).Methods A retrospective study was conducted on 155 NSCLC patients admitted to our hospital from June 2020 to December 2022.They were divided into a control group(traditional lobectomy,n=75)and an observation group(total thoracoscopic lobectomy,n=80)based on different surgical methods.The perioperative indicators and stress response indicators of the two groups were compared,including adrenocorticotropic hormone(ACTH),growth hormone,cortisol,substance P,Interleukin-6(IL-6),interleukin 12(IL-12),Interferon-γ(IFN-γ)Horizontal,etc.Results The operation time,intraoperative blood loss,and postoperative drainage volume in the observation group were better than those of the control group(P<0.05),and there was no statistical difference in the number of lymph node dissection between the two groups(P>0.05).The levels of ACTH,growth hormone,cortisol,and substance P in the observation group were lower than those in the control group(P<0.05).The levels of IL-6,IL-12,and IFN-γin the observation group were lower than those in the control group(P<0.05).The forced vital capacity and peak expiratory flow rate in the observation group were higher than those in the control group(P<0.05).Conclusion The application of total thoracoscopic lobectomy in the treatment of patients with non-small cell lung cancer can reduce surgical trauma and stress response,improve inflammatory response and respiratory function,and promote postoperative rehabilitation.

关 键 词：全胸腔镜肺叶切除术 非小细胞肺癌 应激反应 炎症反应 

分 类 号：R734.2[医药卫生—肿瘤]