注射单倍和半倍剂量钆贝葡胺对臂丛神经增强MRI的对比研究  

Comparative study of the effect of single and half doses of MR contrast agent Gd-BOPTA on the brachial plexus magnetic resonance imaging

作　　者：陈思 赵梦寒 尤贺泽 苏慧琳 张晓晶 CHEN Si;ZHAO Menghan;YOU Heze;SU Huilin;ZHANG Xiaojing(Department of Radiology,The First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]中国人民解放军总医院第一医学中心放射诊断科,北京100853

出　　处：《医学影像学杂志》2023年第10期1769-1773,共5页Journal of Medical Imaging

摘　　要：目的探讨使用对比剂钆贝葡胺(Gd-BOPTA)单倍剂量与半倍剂量对臂丛神经(brachial plexus,BP)增强MRI的影响。方法选取行MRI的BP损伤患者39例,随机分为A、B两组,A组20例,B组19例。A组使用Gd-BOPTA的单倍剂量0.1 mmol/kg,B组使用Gd-BOPTA的半倍剂量0.05 mmol/kg,两组注射速率为1.5 ml/s,以相同速率注射生理盐水20 ml,应用高压注射器将对比剂和生理盐水全部注射完毕后行3D SPACE STIR序列扫描,用最大密度投影对BP进行三维重建,测量左右两侧BP颈6(C6)及其周围软组织的平均信号值(SI)和均方差(SD),根据公式计算左右两侧BP的信噪比(SNR)和对比噪声比(CNR)。结果注射对比剂前平扫BP的SNR为20.723±9.808,CNR为6.626±4.498;B组增强后BP的SNR为35.106±12.264,CNR为15.844±6.634;B组增强后与平扫BP的SNR与CNR对比差异有统计学意义(P<0.05);A组增强后BP的SNR为40.665±25.270,CNR为20.244±15.173,A、B两组增强后的SNR与CNR比较差异无统计学意义(P>0.05);平扫BP图像评分为1.500±0.421,B组增强后BP图像评分为3.454±0.457,两者比较差异有统计学意义(P<0.05);A组增强后BP图像评分为3.575±0.245,A、B两组增强后BP图像质量比较差异无统计学意义(P>0.05)。结论使用半倍剂量的Gd-BOPTA可以满足临床BP增强MRI的需求,在今后的工作中可使用半倍剂量的Gd-BOPTA行BP增强MRI扫描。Objective To conduct a comparative study of the effects of single and half-dose of the magnetic resonance contrast agent Gd-BOPTA on brachial plexus magnetic resonance imaging.Methods A total of 39 patients with brachial plexus(BP)MR imaging in our hospital were collected.39 patients were randomly divided into two groups,with 20 in group A and 19 in group B.group A used the contrast agent Gd-BOPTA at a dose of 0.1 mmol/kg,group B used the contrast agent Gd-BOPTA at a dose of 0.05 mmol/kg,the injection rate was 1.5 ml/s,and the same rate was injected 20 ml Saline.After using high-pressure syringe to inject the contrast agent and saline,the 3D SPACE STIR sequence was started to scan immediately.Three-dimensional image reconstruction of brachial plexus nerves was performed with Maximal intensity projection(MIP).The SI and SD of MIP images reconstructed were calculated for ROI on both sides of C6 peripheral nerves(ROInerve),in regions outside the anatomy(ROIbackground),and tissue adjacent to the peripheral nerves(ROItissue).then SNR and CNR were calculated.Results The SNR of BP nerve before injecting with contrast was 20.723±9.808,and the CNR was 6.626±4.498;The SNR of the BP nerve of group B after injection of the half-dose of Gd-BOPTA was 35.106±12.264 and CNR was 15.844±6.634;P<0.05,the differences were statistically significant between without contrast and group B.The SNR of BP nerve of group A was 40.665±25.270 and CNR was 20.244±15.173;The result of independent sample t test was P>0.05,the differences between group A and B was not statistically significant.The score of BP image without injection of contrast agent was 1.500±0.421,and the score of BP image with half-dose Gd-BOPTA in group B was 3.454±0.457.The paired t test was P<0.05,and the difference was statistically significant;The score of the BP with a single-dose Gd-BOPTA in group A was 3.575±0.245,independent sample t tes t was P>0.05,there was no significant difference between them.Conclusion The BP MR imaging can meet the needs of clinical usi

关 键 词：臂丛神经 钆贝葡胺 图像质量 磁共振成像 

分 类 号：R745.4[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]