中医药治疗胃癌术后胃肠功能障碍的研究进展  

Chinese Medicine in Treatment of Gastrointestinal Dysfunction After Gastric Cancer Surgery:A Review

作　　者：张国磊 王宇立 韩力[1] 韩奇成 宋利杰 康宁 方志红[1] ZHANG Guolei;WANG Yuli;HAN Li;HAN Qicheng;SONG Lijie;KANG Ning;FANG Zhihong(Shanghai Municipal Hospital of Traditional Chinese Medicine(TCM)Affiliated to Shanghai University of TCM,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《中国实验方剂学杂志》2023年第21期238-244,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市科学技术委员会项目(22Y11921300);上海市自然科学基金项目(19ZR1452200);上海市全国中医药创新骨干人才培训项目(2019年);上海市卫生和计划生育委员会中医特色诊疗技术提升项目(zyjx-2017010);上海市卫生和计划生育委员会科研课题项目(201740059)。

摘　　要：胃癌是我国发病率最高的消化系统肿瘤,是严重危害我国民众生命健康的重大疾病,手术是胃癌主要治疗方式之一,术后胃肠功能障碍(PGD)是术后最常见的并发症之一。PGD的发病机制尚不明确,现代医学缺乏高效、针对性的药物,治疗措施较为局限,难以有效改善胃肠功能,影响生活质量及远期预后,存在治疗困境。PGD可归属于中医学“呕吐”“痞满”“胃反”“腹胀”“肠痹”“肠结”等范畴。近年来,众多中医药学者对胃癌PGD展开了大量研究,并取得了诸多研究成果。基于此种研究背景,文章结合近年来中医药治疗胃癌PGD的相关文献,分别从PGD的现代医学认识、中医病因病机、辨证治疗、临床研究等方面进行介绍,对近年来中医药治疗胃癌PGD的研究进展作一综述。研究发现中医药治疗胃癌PGD方式多样,包括中药内服、中药灌肠、耳穴压豆、穴位贴敷、针刺、艾灸等内外治法,具有操作简单、不良反应小、疗效确切、联合治疗效果显著等优势。该文系统整理了中医药治疗胃癌PGD的治疗措施,阐述了中医药治疗胃癌PGD的治法思路,归纳总结了中医药治疗胃癌PGD的研究成果,同时也指出了当前中医药治疗胃癌PGD的不足,并对未来中医药治疗胃癌PGD的研究方向进行了展望,可为中医药治疗胃癌PGD的研究提供一定参考。Gastric cancer is the most prevalent gastrointestinal tumor in China,threatening the life and health of patients.Surgery is one of the available therapies,which,however,induces postoperative gastrointestinal dysfunction(PGD)and other common complications.The pathogenesis of PGD is still unclear and no efficient targeted drug is available.In addition,the limited treatment measures fail to effectively improve gastrointestinal function.As a result,patients generally suffer from low quality of life and poor prognosis.In Chinese medicine,PGD belongs to the categories of"vomiting","stuffiness and fullness","regurgitation","abdominal distension","intestinal impediment",and"intestinal accumulation".In recent years,there has been an explosion of research on the PGD of gastric cancer in Chinese medicine,and many research results have been obtained.On this basis,this study introduced PGD in modern medicine,and causes and pathogenesis,syndrome differentiation-based treatment,and clinical studies of PGD.It was found that diverse internal and external treatments are available in Chinese medicine for PGD such as internal use of Chinese medicine,Chinese medicine enema,auricular point seed-embedding,acupuncture,and moxibustion,which feature ease of implementation,small side effects,definite efficacy,and significant effect in combination with other therapies.This paper summarized the ideas and measures for treatment of PGD of gastric cancer by Chinese medicine,the research outcomes,limitations,and research directions,which can serve as a reference for further research on treatment of PGD of gastric cancer by Chinese medicine.

关 键 词：中医药 胃癌术后 胃肠功能障碍 研究进展 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学] R2-031R287