肠道微生物与缺血性脑卒中相关性研究进展  

Advances in the correlation between ischemic stroke and gut microbiota

作　　者：王璇(综述) 杨军(审校)[1] WANG Xuan;YANG Jun(Department of Neurology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院神经内科,重庆400016

出　　处：《重庆医学》2023年第20期3171-3176,共6页Chongqing medicine

基　　金：国家自然科学基金项目(82201688)。

摘　　要：急性缺血性脑卒中(AIS)作为一种以高发病、高死亡、高致残、高复发为特征的脑血管疾病,近年来越来越多的研究表明AIS与肠道微生物通过微生物-肠-脑轴产生关联,微生物-肠-脑轴的研究也为探索AIS的机制与风险因素开拓了更广阔的思路。该综述从历史演变、肠道微生物与AIS间的关系,以及相关治疗等方面对肠道微生物及AIS之间的联系进行叙述,以期为临床治疗提供参考。As a cerebrovascular disease characterized by high incidence,high mortality,high disability and high recurrence,in recent years more and more studies show that acute ischemic stroke(AIS)is associated with gut microbiota through the microbiota-gut-brain axis.The study of microbiota-gut-brain axis also opens up broader ideas for exploring the mechanism and risk factors of acute ischemic stroke.This review described the historical evolution,the relationship between gut microbiota and ischemic stroke and treatment,so as to provide reference for clinical treatment.

关 键 词：肠道微生物 急性缺血性脑卒中 微生物-肠-脑轴 三甲胺-N-氧化物 短链脂肪酸 综述 

分 类 号：R743.3[医药卫生—神经病学与精神病学]