Abnormal liver function in children hospitalized with acute respiratory infection of adenoviruses:a retrospective study  

作　　者：Xingui Tian Xiao Li Shuyan Qiu Rong Zhou Wenkuan Liu 

机构地区：[1]State Key Laboratory of Respiratory Disease,National Clinical Research Center for Respiratory Disease,Guangzhou Institute of Respiratory Health,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou Medical University,Guangzhou,510182,China

出　　处：《Virologica Sinica》2023年第5期735-740,共6页中国病毒学（英文版）

基　　金：This study was supported by the National Natural Science Foundation of China(82072264,81970003);Natural Science Foundation of Guangdong Province,China(2021A1515011071);The study sponsors had no involvement in the study design,in the collection,analysis and interpretation of data,in the writing of the manuscript,and in the decision to submit the manuscript for publication.

摘　　要：Human adenoviruses(HAdVs)can cause acute hepatitis in immunocompromised patients.However,it is unclear whether HAdVs are contributors to hepatitis in immunocompetent children.In this study,the liver function test(LFT)results were retrospectively analyzed among children hospitalized(age<14 years)between January 2016 and October 2019 for acute respiratory infection caused by adenoviruses.Alanine transaminase(ALT)and aspartate aminotransferase(AST)levels were elevated in 7.74%and 46.89%of patients,respectively.All patients with>2 folds of the upper limit of ALT or AST levels were infected with HAdV-7 or HAdV-55.Significantly higher levels of ALT,AST,γ-glutamyl transpeptidase(γ-GT),and lower albumin levels were observed in the HAdV-7 infection group than in the HAdV-3 infection group.HAdV-55 infection led to significantly higherγ-GT,total bilirubin,and direct bilirubin levels than the other infection types.The records of four patients with serial monitoring of the LFT results were further analyzed.Multiple indicators remained abnormal during the entire hospitalization in these patients.These results indicate that HAdV infection is often accompanied by abnormal liver function,and HAdV-7 and HAdV-55 might be under-recognized contributors to hepatitis among children.

关 键 词：Acute respiratory disease ADENOVIRUS HEPATITIS Liver enzyme Liver function test 

分 类 号：R186[医药卫生—流行病学]