超声、MRI联合血清学对卵巢肿瘤诊断价值  

Diagnostic Value of Ultrasound,MRI Combined with Serology in Ovarian Tumor

作　　者：玄中乾 李亚敏[1] XUAN Zhong-qian;LI Ya-min(Department of Ultrasound,Puyang People's Hospital,Puyang 457000,Henan Province,China)

机构地区：[1]濮阳市人民医院超声科,河南濮阳457000

出　　处：《罕少疾病杂志》2023年第10期62-64,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨超声、MRI联合血清学对卵巢肿瘤的诊断价值。方法将本院2020年3月~2022年6月收治的121例卵巢肿瘤患者作为研究对象,所有患者均行经阴道彩色多普勒超声、MRI及血清糖类抗原125(CA125)、糖类抗原724(CA724)、人附睾蛋白4(HE4)水平检测。以手术病理结果为金标准,将纳入研究者分为恶性组与良性组,对比此两组经阴道彩色多普勒超声、MRI检查结果及血清CA125、CA724、HE4水平;分析各项检查单独及联合对卵巢良恶性肿瘤的诊断价值。结果经手术病理检查,最终确诊为恶性卵巢肿瘤患者46例(恶性组),良性卵巢肿瘤患者75例(良性组)。恶性组与良性组的经阴道彩色多普勒超声图像在形态、回声、包膜、血管搏动指数(PI)、阻力指数(RI)等方面差异均有统计学意义(P<0.05),MRI图像在形态、边界、强化程度、成分方面差异均有统计学差异(P<0.05);恶性组血清CA125、CA724、HE4水平均高于良性组(P<0.05);经阴道彩色多普勒超声检查结果中有48例诊断为恶性卵巢肿瘤,其中有14例假阳性,其诊断卵巢恶性肿瘤的灵敏度、特异度、准确度分别为73.91%、81.33%、78.51%;MRI检查结果中有52例诊断为恶性卵巢肿瘤,其中有15例假阳性,其诊断卵巢恶性肿瘤的灵敏度、特异度、准确度分别为80.43%、80.00%、80.17%;受试者工作特征曲线(ROC)分析结果显示血清CA125、CA724、HE4联合鉴别诊断卵巢恶性肿瘤的灵敏度、特异度和曲线下面积(AUC)分别为76.09%、84.00%和0.793,其灵敏度和AUC均高于各血清指标单独诊断(P<0.05);经阴道彩色多普勒超声、MRI联合血清学检测诊断卵巢恶性肿瘤的灵敏度、特异度、准确度分别为95.65%、88.00%、90.08%,其灵敏度、准确度均高于单独诊断(P<0.05)。结论经阴道彩色多普勒超声、MRI及血清学检测均对卵巢良恶性肿瘤鉴别具有一定的诊断价值,但三者联合诊断效能更高。Objective To investigate the diagnostic value of ultrasound,MRI combined with serology in ovarian tumor.Methods A total of 121 patients with ovarian tumor admitted to our hospital from March 2020 to June 2022 were selected as research subjects.All patients underwent transvaginal color Doppler ultrasound,MRI and serum carbohydrate antigen 125(CA125),carbohydrate antigen 724(CA724)and human epididymal protein 4(HE4)detection.Taking the surgical pathology results as the gold standard,the enrolled researchers were divided into the malignant group and the benign group.The results of transvaginal color Doppler ultrasound,MRI and serum CA125,CA724 and HE4 levels were compared between the two groups.The diagnostic value of each test separately and in combination for benign and malignant ovarian tumors were analyzed.Results 46 cases were finally diagnosed as malignant ovarian tumor(malignant group)and 75 cases were diagnosed as benign ovarian tumor(benign group)by surgical and pathological examination.The transvaginal color Doppler ultrasound images between the malignant group and the benign group showed statistically significant differences in morphology,echo,capsule,vascular pulsation index(PI)and resistance index(RI)(P<0.05),and the MRI images showed statistically significant differences in morphology,boundary,enhancement degree and composition(P<0.05).The levels of serum CA125,CA724 and HE4 in malignant group were higher than those in benign group(P<0.05).48 cases were diagnosed as malignant ovarian tumors by transvaginal color Doppler ultrasound,and 14 cases were false positive among them,and the sensitivity,specificity and accuracy in diagnosing ovarian malignant tumors were 73.91%,81.33%and 78.51%respectively.52 cases were diagnosed as malignant ovarian tumors by MRI,and 15 cases were false positive among them,and the sensitivity,specificity and accuracy of MRI in diagnosing malignant ovarian tumors were 80.43%,80.00%and 80.17%respectively.Receiver operating characteristic curve(ROC)analysis showed that the sensiti

关 键 词：经阴道彩色多普勒超声 核磁共振成像 糖类抗原 人附睾蛋白4 卵巢肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]