初始维生素D、NGF与初发溃疡性结肠炎病情活动性、疗效的关系  

The Relationship between Initial Vitamin D,NGF and Disease Activity and Curative Effect of Initial Ulcerative Colitis

作　　者：张馨心 刘亚清[1] 崔永辉[1] 许春进[1] Zhang Xin-xin;LIU Ya-qing;CUI Yong-hui;XU Chun-jin(Department of Gastroenterology,Shangqiu First People's Hospital,Shangqiu 476000,Province,China)

机构地区：[1]商丘市第一人民医院消化内科,河南商丘476000

出　　处：《罕少疾病杂志》2023年第10期65-67,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的分析初始维生素D、神经生长因子(Nerve growth factor,NGF)与初发溃疡性结肠炎(ulcerative colitis,UC)病情活动性、疗效的关系。方法选取2020年7月-2022年3月本院收治125例初发UC患者为研究对象,根据病情分级(应用改良Mayo评分评价疾病严重程度分型)分为缓解期、活动期[轻度及中度(柳氮磺吡啶)、重度(美沙拉嗪肠溶片+醋酸泼尼松片)]。对比不同病情程度的初始维生素D、NGF水平,采用Pearson相关性分析两者相关性;分析UC患者临床疗效,采用多元Logistic回归分析UC患者临床疗效的影响因素,采用Pearson相关性分析初始维生素D、NGF水平与各项指标的相关性。结果重度(36.22±5.61nmol/L)、中度组(46.28±7.06nmol/L)初始维生素D低于轻度组(57.39±8.42nmol/L),重度(46.38±10.69pg/L)、中度组(39.26±8.43pg/L)NGF水平高于轻度组(30.42±6.38pg/L),重度组初始维生素D低于中度组,NGF水平高于中度组(P<0.05)。初始维生素D与活动期内镜下分级呈负相关(r=-0.416,P<0.05),NGF与活动期内镜下分级呈正相关(r=0.343,P<0.05)。临床疗效有效组106例(84.80%),无效组19例(15.20%),两组WBC、PLT、ESR、血红蛋白、CRP、改良Mayo评分、初始维生素D及NGF水平比较具有统计学差异(P<0.05)。经Logistic回归模型分析得知:WBC、PLT、ESR、血红蛋白、CRP、改良Mayo评分、初始维生素D及NGF水平是影响UC患者疗效的相关因素(P<0.05)。初始维生素D水平与WBC、PLT、ESR、血红蛋白、CRP、改良Mayo评分呈正相关(r=0.263、0.425、0.391、0.372、0.469,P<0.05),NGF水平与上述指标呈负相关(r=-0.371、-0.438、-0.522、-0.395、-0.488,P<0.05)。结论初始维生素D、NGF与初发UC病情活动性、疗效具有紧密联系,初发UC患者病情发展、规范化治疗效果欠佳可能与维生素D、NGF水平异常有关。Objective To analyze the relationship between initial vitamin D,nerve growth factor(NGF)and disease activity and curative effect of initial ulcerative colitis(UC).Methods 125 patients with newly diagnosed UC admitted to our hospital from July 2020 to March 2022 were selected as the research subjects,according to the disease classification,according to the disease classification(modified Mayo score was used to evaluate the disease severity classification),the patients were classified into remission,active(mild and moderate(sulfoazine),and severe(mesalazine enteric-coated tablets+prednisone acetate tablets).The initial vitamin D and NGF levels of different disease degrees were compared,and the Pearson correlation was used to analyze the correlation between the two;to analyze the clinical efficacy of UC patients,multiple logistic regression was used to analyze the influencing factors of clinical efficacy of UC patients,Pearson correlation was used to analyze the correlation between initial vitamin D,NGF levels and various indicators.Results The initial vitamin D level in the severe(36.22±5.61nmol/L)and moderate groups(46.28±7.06nmol/L)was lower than that in the mild group(57.39±8.42nmol/L),NGF levels in severe(46.38±10.69pg/L)and moderate groups(39.26±8.43pg/L)was higher than that in the mild group(30.42±6.38pg/L),the initial vitamin D level in the severe group was lower than that in the moderate group,and the level of NGF in the severe group was higher than that in the moderate group(P<0.05).The initial vitamin D was negatively correlated with the endoscopic grading at the active stage(r=-0.416,P<0.05),and NGF was positively correlated with the endoscopic grading at the active stage(r=0.343,P<0.05).There were 106 patients in the effective group and 19 patients in the ineffective group.There were significant differences between the two groups in WBC,PLT,ESR,hemoglobin,CRP,modified Mayo score,initial vitamin D and NGF levels(P<0.05).There were significant differences in WBC,PLT,ESR,hemoglobin,CRP,modified Mayo

关 键 词：初始维生素D NGF 初发溃疡性结肠炎 病情活动性 疗效 

分 类 号：R574.62[医药卫生—消化系统]