Kaempferol and its derivatives:Biological activities and therapeutic potential  

作　　者：Shazia Parveen Irshad Ul Haq Bhat Rajeev Bhat 

机构地区：[1]Chemistry Department,Faculty of Science,Taibah University,Yanbu Branch,Yanbu-46423,Saudi Arabia [2]Department of Chemistry,College of Science,University of Bahrain,P.O.Box 32038,Bahrain [3]ERA-Chair for Food(By-)Products Valorisation Technologies,Estonian University of Life Sciences,Tartu-510014,Estonia,EU

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第10期411-420,共10页亚太热带生物医学杂志（英文版）

摘　　要：Kaempferol,a natural plant-origin flavonoid,exhibits therapeutic anti-inflammatory,antioxidant,anticancer,antidiabetic,and neuroprotective properties.Kaempferol acts within several distinct mechanisms like apoptotic induction in cancer cells,enzymatic inhibition,signalling pathway inhibition,and downregulation in cell viability during the G2/M phase of cell division.This review summarizes the therapeutic effects of kaempferol against several health ailments.The recent progress on kaempferol obtained from fruits and vegetables as an antioxidant,anti-inflammatory,anticancer,antidiabetic,and neuroprotective agent and its mechanisms of action are also discussed.In addition,kaempferol has been reported to be present in wastes and byproducts from post-fruit and vegetable processing.Thus,a paradigm shift towards valorizing fruits and vegetable industrial wastes/byproducts to obtain bioactive kaempferol can support the circular economy pillar for generating wealth from waste and for finding a sustainable alternative source.

关 键 词：KAEMPFEROL Therapeutic effects BIOACTIVITIES Fruits and vegetable wastes Sustainable alternative sources 

分 类 号：R965[医药卫生—药理学]