乳腺癌放疗抵抗机制的研究进展  

Research Progress on the Mechanism of Radiotherapy Resistance in Breast Cancer

作　　者：毕月 BI Yue(First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院,广东广州510080

出　　处：《中国医学创新》2023年第30期172-176,共5页Medical Innovation of China

基　　金：国家自然科学基金青年项目(81903119);中山大学高校基本科研业务费青年教师培育项目(20ykpy52)。

摘　　要：放疗是鼻咽癌、乳腺癌及直肠癌等多种恶性肿瘤的重要治疗手段,不过部分患者会出现放疗抵抗的现象,造成转移及复发,从而降低患者生存率。乳腺癌患者放疗抵抗的发生与多种因素有关,如肿瘤干细胞及肿瘤微环境等。乳腺癌放疗患者的治疗效果与放疗抵抗密切相关,对放疗抵抗的产生机制进行研究有助于减少或者抑制放疗抵抗,提高放疗效果,改善患者预后。本文从肿瘤干细胞、自噬性调节及DNA损伤修复等多个方面做一综述,旨在为随后研究提供思路。Radiotherapy is an important treatment method for nasopharyngeal carcinoma,breast cancer,rectal cancer and other malignant tumors.However,some patients may experience resistance to radiotherapy,which may cause metastasis and recurrence,thus reducing the survival rate of patients.The occurrence of radiotherapy resistance in breast cancer patients is related to many factors,such as cancer stem cell and tumor microenvironment.The therapeutic effect of breast cancer patients undergoing radiotherapy is closely related to their resistance to radiotherapy.Studying the mechanism of resistance to radiotherapy can help reduce or inhibit resistance to radiotherapy,improve the effect of radiotherapy,and improve the prognosis of patients.This article reviews cancer stem cell,autophagy regulation,DNA damage repair and other aspects in order to provide ideas for subsequent research.

关 键 词：乳腺癌 放疗抵抗 肿瘤干细胞 自噬性调节 细胞周期调控 上皮间充质转化 DNA损伤修复 

分 类 号：R737.9[医药卫生—肿瘤]