双能CT扫描联合血清HMGA2和STAT3检测对早期原发性肝癌患者的诊断价值分析  

Diagnostic Value of Dual Energy CT Scanning Combined with Serum HMGA2 and STAT3 in Patients with Early Primary Liver Cancer

作　　者：金长海 王芳[2] 李艳红 李保卫[2] 杨小英 李志加 贺晓磊 张辉[2] Jin Chang-hai;Wang Fang;Li Yan-hong;Li Bao-wei;Yang Xiao-ying;Li Zhi-jia;He Xiao-lei;Zhang Hui(Radiology Department of Handan First Hospital,Handan 056001,Hebei Province,China;Medical Imaging Department of Hebei Engineering University Affiliated Hospital,Handan 056001,Hebei Province,China;CT Room of Handan Traditional Chinese Medicine Hospital,Handan 056000,Hebei Province,China;CT Room of the Third Hospital of Handan City,Handan 056001,Hebei Province,China;Department of Oncology,Affiliated Hospital of Hebei University of Engineering,Handan 056001,Hebei Province,China)

机构地区：[1]邯郸市第一医院放射科,河北邯郸056001 [2]河北工程大学附属医院医学影像科,河北邯郸056001 [3]邯郸市中医院CT室,河北邯郸056000 [4]邯郸市第三医院CT室,河北邯郸056001 [5]河北工程大学附属医院肿瘤一科,河北邯郸056001

出　　处：《中国CT和MRI杂志》2023年第10期125-127,共3页Chinese Journal of CT and MRI

基　　金：河北省卫生健康委员会资助项目(20220669)。

摘　　要：目的探讨双能CT扫描联合血清高迁移率族蛋白A2(H MGA2)、信号转导和转录激活因子3(STAT3)检测对早期原发性肝癌患者的诊断价值。方法选取2019年4月~2022年4月在我院诊治的早期原发性肝癌患者95例为研究组,另外随机选取本院行上腹部CT平扫及增强扫描,但临床诊断无肝脏、脾脏等相关疾病的65例体检者作为对照组。对早期原发性肝癌患者进行双能CT扫描检查,采用酶联免疫吸附法检测血清中HMGA2、STAT3的表达水平;受试者工作特征曲线(ROC)分析血清HMGA2、STAT3对早期原发性肝癌的诊断价值,评价双能C丁扫描联合血清HMGA2、STAT3对早期原发性肝癌的诊断效能。结果双能CT扫描检查结果显示,早期原发性肝癌患者87例、非肝癌者73例,双能CT扫描诊断早期原发性肝癌的灵敏度为76.84%(73/95),特异度为78.46%(51/65),准确度为77.50%(124/160)。与对照组相比,早期原发性肝癌患者血清HMGA2、STAT3表达水平显著增高,差异有统计学意义(P<0.05)。血清HMGA2诊断早期原发性肝癌的曲线下面积为0.924(95%CI:0.871~0.960),灵敏度为85.26%,特异度为90.77%,最佳截断值为48.75mg/L5血清STAT3诊断早期原发性肝癌的曲线下面积为0.843(95%CI:0.777~0.896),灵敏度为84.21%,特异度为69.23%,最佳截断值为0.99mg/L。双能CT扫描联合血清HMGA2、STAT3诊断早期原发性肝癌的灵敏度为88.42%、特异度为89.23%,准确度为88.75%。结论早期原发性肝癌患者血清HMGA2和STAT3表达水平显著升高,双能CT扫描联合血清HMGA2、STAT3在诊断早期原发性肝癌中的诊断效能较高,临床应用价值较大。Objective To investigate the diagnostic value of dual energy CT scanning combined with detection of serum high mobility group A2(HMGA2),signal transducer and activator of transcription 3(STAT3)in patients with early primary liver cancer.Methods From April 2019 to April 2022,95 patients with early primary liver cancer diagnosed and treated in our hospital were selected as the study group,in addition,65 physical examiners who had undergone plain and enhanced CT scans of upper abdomen in our hospital but had no clinical diagnosis of liver,spleen and other related diseases were randomly selected as the control group.Dual energy CT scanning was performed in patients with early primary liver cancer,and the expression levels of HMGA2 and STAT3 in serum were detected by enzyme-linked immunosorbent assay;ROC was applied to analyze the diagnostic value of serum HMGA2 and STAT3 in early primary liver cancer,and the diagnostic efficacy of dual energy CT scanning combined with serum HMGA2 and STAT3 for early primary liver cancer was evaluated.Results The results of dual energy CT scanning showed that 87 patients with early primary liver cancer and 73 patients without liver cancer,the sensitivity,specificity and accuracy of dual energy CT in the diagnosis of early primary liver cancer were 76.84%(73/95),78.46%(51/65)and 77.50%(124/160),respectively.Compared with the control group,the expression levels of HMGA2 and STAT3 in serum of patients with early primary liver cancer were obviously higher(P<0.05).The area under the curve of serum HMGA2 in the diagnosis of early primary liver cancer was 0.924(95%CI:0.871-0.960),the sensitivity was 85.26%,the specificity was 90.77%,and the optimal cut-off value was 48.75mg/L;the area under the curve of serum STAT3 in the diagnosis of early primary liver cancer was 0.843(95%CI:0.777-0.896),the sensitivity was 84.21%,the specificity was 69.23%,and the optimal cut-off value was 0.99mg/L.The sensitivity,specificity and accuracy of dual energy CT scanning combined with serum HMGA2 and STAT3 in t

关 键 词：早期原发性肝癌 双能CT扫描 高迁移率族蛋白A2 信号转导和转录激活因子3 临床诊断 

分 类 号：R735.7[医药卫生—肿瘤]