Surface defect engineered-Mg-based implants enable the dual functions of superhydrophobic and synergetic photothermal/chemodynamic therapy  

作　　者：Dongdong Zhang Ru Xu Shuhan Chen Huihui Du Shi Qian Feng Peng Xuanyong Liu 

机构地区：[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai,200050,China [2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,100049,China [3]Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma,The University of Hong Kong Shenzhen Hospital,Shenzhen,China [4]Center for Human Tissues and Organs Degeneration,Shenzhen Institutes of Advanced Technology,Chinese Academy of Science,Shenzhen,518055,PR China [5]Medical Research Institute,Department of Orthopedics,Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences),Southern MedicalUniversity,Guangzhou,510080,China [6]GuangDong Engineering Technology Research Center of Functional Repair of Bone Defects and Biomaterials,Guangzhou,510080,China [7]School of Chemistry and Materials Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,1 Sub-lane Xiangshan,Hangzhou,310024,China

出　　处：《Bioactive Materials》2023年第12期15-28,共14页生物活性材料（英文）

基　　金：the National Key R&D Program of China(2021YFC2400500);Shanghai Committee of Science and Technology,China(20S31901200);GDPH Supporting Fund for Talent Program(KY0120220137 and KY012021462);Postdoctoral Science Foundation of China(2022M723288).

摘　　要：Promoting metallic magnesium(Mg)-based implants to treat bone diseases in clinics,such as osteosarcoma and bacterial infection,remains a challenging topic.Herein,an iron hydroxide-based composite coating with a twostage nanosheet-like structure was fabricated on Mg alloy,and this was followed by a thermal reduction treatment to break some of the surface Fe–OH bonds.The coating demonstrated three positive changes in properties due to the defects.First,the removal of–OH made the coating superhydrophobic,and it had self-cleaning and antifouling properties.This is beneficial for keeping the implants clean and for anti-corrosion before implantation into the human body.Furthermore,the superhydrophobicity could be removed by immersing the implant in a 75%ethanol solution,to further facilitate biological action during service.Second,the color of the coating changed from yellow to brown-black,leading to an increase in the light absorption,which resulted in an excellent photothermal effect.Third,the defects increased the Fe2+content in the coating and highly improved peroxidase activity.Thus,the defect coating exhibited synergistic photothermal/chemodynamic therapeutic effects for bacteria and tumors.Moreover,the coating substantially enhanced the anti-corrosion and biocompatibility of the Mg alloys.Therefore,this study offers a novel multi-functional Mg-based implant for osteosarcoma therapy.

关 键 词：Magnesium-based implants Surface defects SUPERHYDROPHOBIC ANTI-BACTERIAL ANTI-TUMOR 

分 类 号：R318[医药卫生—生物医学工程]