Complex coacervate-derived hydrogel with asymmetric and reversible wet bioadhesion for preventing UV light-induced morbidities  

作　　者：Xin Peng Yuan Li Menghui Liu Zhuo Li Xuemei Wang Kunyu Zhang Xin Zhao Gang Li Liming Bian 

机构地区：[1]Guangdong Provincial Engineering Research Center of Molecular Imaging,The Fifth Affiliated Hospital,Sun Yat-sen University,Zhuhai,519000,China [2]Department of Orthopaedics&Traumatology,Stem Cells and Regenerative Medicine Laboratory,Li Ka Shing Institute of Health Sciences,The Chinese University ofHong Kong,Prince of Wales Hospital,Shatin,999077,Hong Kong Special Administrative Region [3]School of Biomedical Sciences and Engineering,Guangzhou International Campus,National Engineering Research Center for Tissue Restoration and Reconstruction,Guangdong Provincial Key Laboratory of Biomedical Engineering,Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education,South ChinaUniversity of Technology,Guangzhou,510006,PR China [4]Department of Biomedical Engineering,The Hong Kong Polytechnic University,Hong Kong

出　　处：《Bioactive Materials》2023年第12期62-72,共11页生物活性材料（英文）

基　　金：the National Key Research and Development Program(2022YFB3804403);the Collaborative Research Fund from the Research Grants Council of Hong Kong(Project No.C5044-21G);the Research Grants Council of the Hong Kong Special Administration Region(project no.GRF/14202920,GRF/14204618,GRF/14108720,T13-402/17-N and AoE/M-402/20);National Natural Science Foundation of China(22205264).

摘　　要：Protecting the skin from UV light irradiation in wet and underwater environments is challenging due to the weak adhesion of existing sunscreen materials but highly desired.Herein we report a polyethyleneimine/thioctic acid/titanium dioxide(PEI/TA/TiO_(2))coacervate-derived hydrogel with robust,asymmetric,and reversible wet bioadhesion and effective UV-light-shielding ability.The PEI/TA/TiO_(2)complex coacervate can be easily obtained by mixing a PEI solution and TA/TiO_(2)powder.The fluid PEI/TA/TiO_(2)coacervate deposited on wet skin can spread into surface irregularities and subsequently transform into a hydrogel with increased cohesion,thereby establishing interdigitated contact and adhesion between the bottom surface and skin.Meanwhile,the functional groups between the skin and hydrogel can form physical interactions to further enhance bioadhesion,whereas the limited movement of amine and carboxyl groups on the top hydrogel surface leads to low adhesion.Therefore,the coacervate-derived hydrogel exhibits asymmetric adhesiveness on the bottom and top surfaces.Moreover,the PEI/TA/TiO_(2)hydrogel formed on the skin could be easily removed using a NaHCO3 aqueous solution without inflicting damage.More importantly,the PEI/TA/TiO_(2)hydrogel can function as an effective sunscreen to block UV light and prevent UV-induced MMP-9 overexpression,inflammation,and DNA damage in animal skin.The advantages of PEI/TA/TiO_(2)coacervate-derived hydrogels include robust,asymmetric,and reversible wet bioadhesion,effective UV light-shielding ability,excellent biocompatibility,and easy preparation and usage,making them a promising bioadhesive to protect the skin from UV light-associated damage in wet and underwater environments.

关 键 词：Adhesive hydrogel COACERVATE Asymmetric adhesion Reversible adhesion 

分 类 号：O64[理学—物理化学]