肝硬化再代偿:现状与挑战  

Recompensation of liver cirrhosis:Current status and challenges

作　　者：冯巩 宋娟娟 叶峰[6] 马永红 任艺琳 张子怡 贺娜 李雪萍[5] 弥曼 FENG Gong;SONG Juanjuan;YE Feng;MA Yonghong;REN Yilin;ZHANG Ziyi;HE Na;LI Xueping;MI Man(Institute of General Practice,Xi’an Medical University,Xi’an 710021,China;School of Public Health,Xi’an Medical University,Xi’an 710021,China;School of General Practice,Xi’an Medical University,Xi’an 710021,China;College of Nursing and Rehabilitation,Xi’an Medical University,Xi’an 710021,China;School of Clinical Medicine,Xi’an Medical University,Xi’an 710021,China;Department of Infectious Diseases,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;Department of Gastroenterology,The First Affiliated Hospital of Xi’an Medical University,Xi’an 710077,China)

机构地区：[1]西安医学院全科医学研究所,西安710021 [2]西安医学院公共卫生学院,西安710021 [3]西安医学院全科医学院,西安710021 [4]西安医学院护理与康复学院,西安710021 [5]西安医学院临床医学院,西安710021 [6]西安交通大学第一附属医院感染科,西安710061 [7]西安医学院第一附属医院消化内科,西安710077

出　　处：《临床肝胆病杂志》2023年第10期2464-2469,共6页Journal of Clinical Hepatology

基　　金：2020陕西省教育厅课题(20JK0343);陕西省中医药管理局中医药传承创新暨“秦药”开发重点科学研究项目;西安医学院2021年校级科研项目(2021QN20)。

摘　　要：传统上,从代偿性肝硬化到失代偿性肝硬化的进展被认为是疾病自然史中的一个不可逆转点,然而,随着潜在病因的抑制、治愈与疾病消退,越来越多的新证据挑战了这一观点,“肝硬化再代偿”的观点逐渐被接受。近年来,关于肝硬化再代偿具体可行的定义及患者的临床特征引发国内外学者的不断探索。本文通过总结近期国内外对“肝硬化再代偿”的研究,整合已有观点并梳理研究证据,指出现阶段再代偿领域面临的挑战主要包括缺乏深层次的临床与基础研究、需定义非酒精性脂肪性肝病背景下的再代偿,以及面临的伦理方面的问题,为该领域未来的研究提供了新的探索方向。Traditionally,the progression from compensated liver cirrhosis to decompensated liver cirrhosis has been considered an irreversible point in the natural history of the disease;however,with the suppression of underlying etiology,cure,and disease regression,this view is challenged by an increasing number of new evidence,and the idea of“recompensation of liver cirrhosis”is gradually being accepted.In recent years,scholars in China and globally have been exploring the specific definition of recompensation of liver cirrhosis and the clinical features of patients.By summarizing the recent studies on recompensation of liver cirrhosis in China and globally,integrating existing views,and analyzing related research evidence,this article points out the main challenges in the field of recompensation at this stage,including the lack of in-depth clinical and basic research,the need to define recompensation in the context of NAFLD,and related ethical issues,in order to provide new directions for future research in this field.

关 键 词：肝硬化 再代偿 病理状态 体征和症状 

分 类 号：R575.2[医药卫生—消化系统]