冷杉属植物化学成分及其药理活性研究进展  

Progress in Research on Chemical Constituents and Pharmacological Activities of Abies

作　　者：谢晓艳 周青青 朱佳雯 潘巍巍[1] 占扎君[2] 谢宝刚 周武 徐金标 XIE Xiao-yan;ZHOU Qing-qing;ZHU Jia-wen;PAN Wei-wei;ZHAN Zha-jun;XIE Bao-gang;ZHOU Wu;XU Jin-biao(College of Medicine,Jiaxing University,Jiaxing 314001,China;College of Pharmacy,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]嘉兴学院医学院,浙江嘉兴314001 [2]浙江工业大学药学院,杭州310014

出　　处：《中国药学杂志》2023年第14期1245-1264,共20页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(82003612);创新嘉兴优才支持计划资助(202106)。

摘　　要：冷杉属植物全球已发现有50余种,我国冷杉资源丰富,有19种3变种,主要分布在云南、四川、甘肃和西藏等地区。自2008年以来,文献已报道了17种冷杉属植物中的700多个化合物,其化学成分主要包括萜类、黄酮类、木脂素类、酚类、少量生物碱类、甾体类、蒽醌类和其他类型化合物,具有抗肿瘤、抗炎、抗菌、抗病毒等药理活性。笔者将对2008年以来冷杉属植物化学成分及药理活性的研究进展进行综述,以期为更多创新药物新化学实体的发现提供参考,并为该属植物珍稀资源的合理开发利用提供科学指导。There are about 50 species of Abies,including 19 species and 3 varieties in China,which mainly distribute in Yunnan,Sichuan,Gansu,and Xizang provinces.Since 2008,more than 700 compounds from 17 species of Abies have been reported in the literature.The chemical compositions mainly include terpenoids,flavonoids,lignans,phenols,a small number of alkaloids,steroids,anthraquinones and other compounds,which show anti-tumor,anti-inflammatory,anti-bacterial,anti-viral and other pharmacological activities.This article reviews the chemical constituents and pharmacological activities of components from Abies reported since 2008.In order to provide reference for the discovery of more new chemical entities of innovative drugs,and provide scientific guidance for the rational development and utilization of rare resources of this genus.

关 键 词：冷杉属 萜类 黄酮类 木脂素类 抗肿瘤 

分 类 号：R914[医药卫生—药物化学]