吡拉西坦治疗脑出血恢复期患者的效果分析  

Analysis on Effect of Piracetam in Treatment of Patients with Cerebral Hemorrhage in Recovery Period

作　　者：杨旭[1] Yang Xu(Department of Neurosurgery,Mianyang Central Hospital,Mianyang 621000,Sichuan Province,China)

机构地区：[1]绵阳市中心医院神经外科,四川绵阳621000

出　　处：《中国社区医师》2023年第28期20-22,共3页Chinese Community Doctors

摘　　要：目的:分析吡拉西坦治疗脑出血恢复期患者的效果。方法:选取2021年10月—2022年10月绵阳市中心医院神经外科收治的100例脑出血恢复期患者作为研究对象,根据随机数字表法分为对照组和观察组,各50例。对照组采用常规治疗,观察组在对照组基础上给予吡拉西坦片治疗。比较两组治疗前后脑血流动力学指标、神经功能缺损状况和认知功能、不良反应发生情况。结果:治疗前,两组血流速度、血流量、外周阻力、临界压力比较,差异无统计学意义(P>0.05);治疗后,观察组血流速度、血流量高于对照组,外周阻力、临界压力低于对照组,差异有统计学意义(P<0.05)。治疗前,两组美国国立卫生研究院卒中量表(NIHSS)、蒙特利尔认知功能评估量表(MoCA)评分比较,差异无统计学意义(P>0.05);治疗后,观察组NIHSS评分低于对照组,MoCA评分高于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:吡拉西坦治疗脑出血恢复期患者的效果显著,能够改善脑血流动力学指标,促进神经功能恢复,改善认知功能,且安全性较高,值得临床应用并予以推广。Objective:To analyze the effect of piracetam in the treatment of patients with cerebral hemorrhage in the recovery period.Methods:A total of 100 patients with cerebral hemorrhage in the recovery period admitted to Department of Neurosurgery,Mianyang Central Hospital from October 2021 to October 2022 were selected as the study subjects.They were divided into the observation group and the control group by using the random digital table method,with 50 patients in each group.The control group received conventional therapy,while the observation group received piracetam treatment on the basis of the control group.The cerebral hemodynamic indexes,neurological deficits and cognitive function before and after treatment,as well as the incidence of adverse reactions were compared between the two groups.Results:Before treatment,there were no significant differences in blood flow velocity,blood flow,peripheral resistance and critical pressure between the two groups(P>0.05).After treatment,the blood flow velocity and blood flow in the observation group were higher than those in the control group,and the peripheral resistance and critical pressure in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference between the two groups in terms of National Institutes of Health Stroke Scale(NIHSS)and Montreal Cognitive Function Assessment Scale(MoCA)(P>0.05).After treatment,the NIHSS score in the observation group was lower than that in the control group,and the MoCA score in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Piracetam has a significant effect in the treatment of patients with cerebral hemorrhage in the recovery period,which can improve cerebral hemodynamic indexes,promote neurological function recovery,ameliorate

关 键 词：脑出血恢复期 吡拉西坦 脑血流动力学 神经功能缺损 认知功能 

分 类 号：R743.34[医药卫生—神经病学与精神病学]