Effectiveness and the nomogram of small incision lenticule extraction in the correction of myopic anisometropia in adults  

作　　者：Tong Zhang Lu Zhu Hang-Jia Zuo Zhi-Jun Chen Yan Ji Xin Yang Xiao-Rong Lu Qiong Wu Qing Wang Jiu-Yi Xia Meng Li Chun-Jiang Zhou Yao Wang Ke Hu Wen-Juan Wan 

机构地区：[1]Nomogram of SMILE surgery for adult anisometropia 1Chongqing Medical University,Chongqing 400000,China [2]The First Affiliated Hospital of Chongqing Medical University,Chongqing Key Laboratory of Ophthalmology,Chongqing Eye Institute,Chongqing Branch(Municipality Division)of National Clinical Research Center for Ocular Diseases,Chongqing 400000,China

出　　处：《International Journal of Ophthalmology(English edition)》2023年第11期1838-1844,共7页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81970832;No.81870650);the Key Project of the Chongqing Health Commission(No.2018MSXM003;No.2018GDRC008);Natural Science Foundation of Chongqing Science and Technology Bureau(No.cstc2021jcyj-msxmX0967).

摘　　要：AIM:To evaluate the safety,effectiveness,and predictability of small incision lenticule extraction(SMILE)for the treatment of anisometropia,and to explore the personalized design scheme of SMILE in correcting adult myopia anisometropia based on the nomogram.METHODS:It’s a prospective cohort study.Patients with anisometropic myopia of refractive difference≥2.0 diopters(D)who underwent SMILE between September 2020 and March 2021 were enrolled.Clinical features and visual function were assessed preoperatively and at 1wk,1,3,and 6mo after the operation.The examination included tests for uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA),refractive errors,effectiveness index(preoperative CDVA/postoperative UDVA),safety index(postoperative CDVA/preoperative CDVA),nomogram and stereoscopic function.Paired t-test,Wilcoxon signed-rank test and repeated-measures analyses of variance were used for continuous variables,and Pearson Chi-squared test was used for categorical variables.RESULTS:The study involved 45 consecutive patients(average age:25.0±6.9y;82 out of 90 eyes underwent SMILE,while 8 eyes were not operated).The average preoperative spherical equivalent(SE)was-4.74±0.22 D.Six months after surgery,the effectiveness index was 1.05±0.12,and the safety index was 1.09±0.11.Seventy eyes(85.4%)exhibited SE correction error within±0.5 D.The percentage of eyes with Titmus stereoscopic function equal to or less than 200”significantly increased from 55.6%preoperatively to 88.9%postoperatively(P<0.05).There was statistically significant difference between higher myopia eyes and contralateral eyes in average nomogram value/spherical refraction ratio.CONCLUSION:SMILE is safe,effective and predictable in correcting myopic anisometropia,and it improves stereoscopic visual function of anisometropia patients.The precise and individualized design of the nomogram is a vital element to ensure the balance of both eyes after SMILE.

关 键 词：refractive surgery small incision lenticule extraction ANISOMETROPIA NOMOGRAM 

分 类 号：R779.6[医药卫生—眼科] R774.5[医药卫生—临床医学]