Atypical bacterial Argonautes regulate antiphage defense  

作　　者：Arpita Chakravarti Dinshaw J.Patel 

机构地区：[1]Structural Biology Program,Memorial Sloan-Kettering Cancer Center,New York,NY,USA

出　　处：《Cell Research》2023年第9期655-656,共2页细胞研究（英文版）

摘　　要：Unusual Argonaute(Ago)proteins have been recently identified in prokaryotic immune systems,which upon binding to foreign nucleic acids,activate their associated NADase effectors.Recent cryo-EM structures of such unique Ago-associated TIR and SIR2 NADases revealed an unconventional nucleic acid binding-mediated NADase activation,adding to the repertoire of canonical cyclic second messenger-driven TIR and SIR2 activation mechanisms.

关 键 词：SIR2 ARGONAUTE activation 

分 类 号：Q2[生物学—细胞生物学]