Pd-Catalyzed Asymmetric Allylic C—H Functionalization  

作　　者：Pu-Sheng Wang Liu-Zhu Gong 

机构地区：[1]Department of Chemistry,University of Science and Technology of China,Hefei,Anhui 230026,China [2]Center for Excellence in Molecular Synthesis of CAS,University of Science and Technology of China,Hefei,Anhui 230026,China

出　　处：《Chinese Journal of Chemistry》2023年第15期1841-1848,共8页中国化学（英文版）

基　　金：the National Key R&D Program of China(2021YFA1500100);Youth Innovation Promotion Association CAS(2020448);NSFC(22171254 and 22188101);Anhui Provincial Natural Science Foundation(2108085MB58);USTC Research Funds of the DoubleFirst-Class Initiative(YD2060002024);Start-up Research Fund from University of Science and Technology of China(KY2060000216).

摘　　要：Comprehensive Summary Pd-catalyzed asymmetric allylic C—H functionalization has emerged as a powerful tool to access chiral,densely functionalized molecules from easily accessible alkenes,enabling the increase of the step-or atom-economy by minimizing functional group manipulations for preparing allylating reagents.Due to the inadequacy of stereoselection strategies,the asymmetric allylic C—H functionalization is still in the early stage.In this essay,we will describe our journey to identification of asymmetric catalytic systems,mechanism of allylic C—H activation,control of stereo-and regioselectivity,and applications in asymmetric synthesis.

关 键 词：C-H activation Asymmetric catalysis ALLYLATION Palladium Allylic compounds Regioselectivity ALKENES 

分 类 号：O621.251[理学—有机化学]