[3+2]Cycloaddition of Vinyl Cyclopropane and Hydroxylamines via Isocynate Intermediate toγ-Lactams  

作　　者：Xiaobing Huang Jingxun Yu Xinjun Luan 

机构地区：[1]Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education,College of Chemitry&Materials Science,Northwest University,Xi'an,Shaanxi 710127,China

出　　处：《Chinese Journal of Chemistry》2023年第16期1937-1942,共6页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(21925108,21901203,21901204)for financial support.

摘　　要：Comprehensive Summary A general and efficient strategy for the synthesis ofγ-lactams has been reported.The hydroxylamines form Lossen rearrangement products of electron-deficient group migration with base and then undergo[3+2]cycloaddition reaction with vinyl cyclopropane,which could be performed with broad substrate scope,excellent functional group tolerance and high efficiency to produce the desired products.It also allowed further modification to other derivatives of theseγ-lactams.

关 键 词：γ-Lactams HYDROXYLAMINES VinyI cyclopropane PD-CATALYZED [3+2]cycloaddition AMINATION Insertion Ring expansion 

分 类 号：O621.25[理学—有机化学]