Derivation of Benzothiadiazine-1,1-dioxide Scaffolds via Transition Metal-Catalyzed C-H Activation/Annulation  

作　　者：Ruizhi Lai Shuran Xu Qingyao Zhang Hui Zhou Cankun Luo Yuerong Wang Li Hai Yong Wu 

机构地区：[1]Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmagy,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Chinese Journal of Chemistry》2023年第16期1973-1978,共6页中国化学（英文版）

基　　金：Sichuan Science and Technology Program(No:2020YJ0221);the Natural Science Foundation of Shandong Province,China(No.ZR2021QH362).

摘　　要：Comprehensive Summary Benzothiadiazine-1,1-dioxide scaffold is bioactive framework with wild utility and applications.Synthesis of benzothiadiazine-fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal-catalyzed C—H activation/annulation was reported.3-Phenyl-2H-benzothiadiazine-1,1-dioxide was used as the reaction substrate,and vinylene carbonate and 4-diazopyrazolone were used as the coupling reagents,respectively.This strategy provides straightforward access to complex N-heterocycles in a highly efficient and simple manner.

关 键 词：C-H activation ANNULATION RUTHENIUM RHODIUM HETEROCYCLES Fused-ring systems Spiro compounds Diazo compounds 

分 类 号：O626[理学—有机化学]