抑郁症患者及一级亲属的脑功能影像研究进展  

The advancement of brain functional imaging in individuals diagnosed with major depressive disorder and their first-degree relatives

作　　者：李峰 张志芳[1] 薄奇静 王传跃 Li Feng;Zhang Zhifang;Bo Qijing;Wang Chuanyue(The National Clinical Research Center for Mental Disorders,Beijing Key Laboratory of Mental Disorders,Beijing Institute for Brain Disorders Center of Schizophrenia,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心、精神疾病诊断与治疗北京市重点实验室、北京脑重大疾病研究院精神分裂症研究所,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069

出　　处：《中华精神科杂志》2023年第5期395-400,共6页Chinese Journal of Psychiatry

基　　金：国家自然科学基金(81901355)。

摘　　要：抑郁症是一种常见的高负担精神疾病,一级亲属高度易感,但患者与亲属间内在神经机制的异同尚不明确,对患者与一级亲属神经影像特征异同的比较可增进对抑郁症病理及易感机制的理解。本文中旨在从常见的神经影像技术出发,对抑郁症患者(包括急性期和缓解期患者)和一级亲属的脑功能影像异同点进行归纳总结及展望,发现皮质-边缘-小脑环路局部脑功能活动及脑功能交互的异常在抑郁症和一级亲属的内在神经机制中至关重要,这一环路也是抗抑郁药的潜在作用靶点。未来研究需进一步阐明失衡的皮质-边缘-小脑环路在抑郁症疾病进程中的作用。Major depressive disorder is a prevalent and burdensome mental illness that exhibits a high degree of heritability.Despite this,the underlying neural mechanisms that contribute to its development remain unclear.To enhance our comprehension of the pathology and susceptibility mechanisms of major depressive disorder,this study aims to compare the neuroimaging characteristics of patients diagnosed with major depressive disorder and their first-degree relatives.The objective of this study is to conduct a comprehensive analysis and synthesis of brain functional images of individuals diagnosed with major depressive disorder,including those in the acute and remission stages,as well as their first-degree relatives,utilizing various prevalent neuroimaging modalities.Additionally,this study aims to identify potential avenues for future research in this area.This study shows that abnormalities in local brain functional activity and functional interactions of the cortical-limbic-cerebellar circuits are critical in intrinsic neural mechanisms of depression and their first-degree relatives,and this circuits is also a potential target for antidepressants.Future studies are needed to further clarify the role of unbalanced cortical-limbic-cerebellar circuits in the disease process of depression.

关 键 词：抑郁症 一级亲属 脑功能 神经影像 

分 类 号：R749.4[医药卫生—神经病学与精神病学]