The role of bacteria and its derived biomaterials in cancer radiotherapy  

作　　者：Yu Zhang Ruizhe Huang Yunchun Jiang Wenhao Shen Hailong Pei Guanglin Wang Pei Pei Kai Yang 

机构地区：[1]State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection&School for Radiological and Interdisciplinary Sciences(RAD-X),Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China [2]Teaching and Research Section of Nuclear Medicine,School of Basic Medical Sciences,Anhui Medical University,Hefei 230032,China

出　　处：《Acta Pharmaceutica Sinica B》2023年第10期4149-4171,共23页药学学报（英文版）

基　　金：partially supported by the National Natural Science Foundation of China(U1932208,32171382);Key Research and Development Program of Social Development of Jiangsu Province(BE2022725,China);Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Research Endowment(CURE,China);Undergraduate Training Program for Innovation and Entrepreneurship Soochow University(202010285046Z,China);the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD,China)。

摘　　要：Bacteria-mediated anti-tumor therapy has received widespread attention due to its natural tumor-targeting ability and specific immune-activation characteristics.It has made significant progress in breaking the limitations of monotherapy and effectively eradicating tumors,especially when combined with traditional therapy,such as radiotherapy.According to their different biological characteristics,bacteria and their derivatives can not only improve the sensitivity of tumor radiotherapy but also protect normal tissues.Moreover,genetically engineered bacteria and bacteria-based biomaterials have further expanded the scope of their applications in radiotherapy.In this review,we have summarized relevant researches on the application of bacteria and its derivatives in radiotherapy in recent years,expounding that the bacteria,bacterial derivatives and bacteria-based biomaterials can not only directly enhance radiotherapy but also improve the anti-tumor effect by improving the tumor microenvironment(TME)and immune effects.Furthermore,some probiotics can also protect normal tissues and organs such as intestines from radiation via anti-inflammatory,anti-oxidation and apoptosis inhibition.In conclusion,the prospect of bacteria in radiotherapy will be very extensive,but its biological safety and mechanism need to be further evaluated and studied.

关 键 词：Bacterial therapy Radiotherapy Engineered bacteria Bacteria-based biomaterials Radio-protector Radio-sensitization Radiation-activation Synergy effect 

分 类 号：R730.5[医药卫生—肿瘤] TB34[医药卫生—临床医学]