妇科恶性肿瘤免疫治疗中国专家共识(2023年版)  

Chinese expert consensus on immunotherapy for gynecological malignant tumors(2023 edition)

作　　者：中国抗癌协会肿瘤内分泌专业委员会 周琦 邹冬玲 孙阳 王丹波[4] 王莉[5] 龙行涛 向阳[6] 黄裕 张师前[7] 王海霞 李因涛 吴绮楠[8] Society of Onco-Endocrinology of Chinese Anti-Cancer Association;ZHOU QI

机构地区：[1]不详 [2]重庆大学附属肿瘤医院 [3]福建省肿瘤医院 [4]辽宁省肿瘤医院 [5]河南省肿瘤医院 [6]中国医学科学院北京协和医院 [7]山东大学齐鲁医院 [8]重庆医科大学附属大足医院

出　　处：《中国癌症杂志》2023年第10期954-968,共15页China Oncology

基　　金：重庆市科技局技术创新与应用发展专项(cstc2019jscx-msxmX0106);重庆英才计划“包干制”项目(基础研究与前沿探索类)(cstc2021ycjh-bgzxm0134);重庆市医学科技创新四大中心建设项目-重庆市卵巢癌专病医学研究中心项目。

摘　　要：免疫治疗作为第四大抗肿瘤治疗方法,已在癌症治疗领域取得了突破性进展,其中免疫检查点抑制剂已广泛应用于多种恶性肿瘤的治疗,在妇科恶性肿瘤领域也积累了较多的临床证据和经验。但目前国内外在免疫检查点抑制剂等免疫疗法应用于妇科恶性肿瘤的治疗方面尚缺乏规范。因此,由中国抗癌协会肿瘤内分泌专业委员会牵头,组织多领域专家,以高质量临床研究结果、2023年美国临床肿瘤学会(American Society of Clinical Oncology,ASCO)会议研究结果等为循证医学依据,通过共同讨论及投票,从而形成《妇科恶性肿瘤免疫治疗中国专家共识(2023年版)》。本共识就妇科常见子宫颈癌、子宫内膜癌、卵巢癌及其他恶性肿瘤分类推荐了免疫检查点抑制剂单药或联合化疗、靶向治疗等临床应用方案。总结了肿瘤疫苗、过继性细胞免疫治疗和细胞因子等免疫治疗在妇科恶性肿瘤中的相关研究及应用情况,供国内同行参考,以期进一步规范妇科恶性肿瘤免疫治疗的临床实践。Immunotherapy,as the fourth largest anti-tumor treatment method,has made breakthrough progress in the field of cancer treatment.Checkpoint inhibitors have been widely used in the treatment of various malignant tumors,and a lot of clinical evidence and experience have also been accumulated in the field of gynecological malignant tumors.However,there is still a lack of standardization in the application of immunotherapy such as immune checkpoint inhibitors for the treatment of gynecological malignant tumors.Therefore,led by the Cancer Endocrine Professional Committee of the China Anti-Cancer Association,experts from multiple fields were organized to use high-quality clinical research results as well as the results of the 2023 American Society of Clinical Oncology(ASCO)conference as evidence.Through discussion and voting,the consensus of Chinese experts on immunotherapy for gynecological malignant tumors(2023 version)has been formed.This consensus recommended the clinical application of immune checkpoint inhibitors for the classification of common gynecological cervical cancer,endometrial cancer,ovarian cancer and other malignant tumors,such as single drug or combination chemotherapy,targeted therapy,etc.It summarized the research and application of tumor vaccines,adoptive cell immunotherapy and cytokine immunotherapy in gynecological malignant tumors,and provided reference for domestic peers,in order to further standardize the clinical practice of immunotherapy for gynecological malignant tumors.

关 键 词：免疫治疗 妇科恶性肿瘤 免疫检查点抑制剂 

分 类 号：R737.3[医药卫生—肿瘤]