多重抗神经元抗体阳性的副肿瘤性自身免疫性脑炎合并肺栓塞1例  

A case report of paraneoplastic autoimmune encephalitis with co-existence of multiple anti-neuronal antibodies combined with pulmonary embolism

作　　者：张萍[1] 李洁[1] 陈万莉 Zhang Ping;Li Jie;Chen Wanli(Department of Neurology,People′s Hospital of Deyang City,Deyang 618000,China)

机构地区：[1]德阳市人民医院神经内科,德阳618000

出　　处：《中华神经科杂志》2023年第10期1174-1178,共5页Chinese Journal of Neurology

摘　　要：副肿瘤性自身免疫性脑炎常见临床表现为癫痫、认知功能下降、情绪行为改变等神经精神症状,合并肺栓塞者少见。而多重抗神经元抗体阳性的副肿瘤性自身免疫性脑炎其临床表现更为复杂,且可能影响预后。文中报道了1例多重神经元抗体阳性的副肿瘤性自身免疫性脑炎合并肺栓塞患者,并复习相关文献,分析其临床特点,以提高对副肿瘤性自身免疫性脑炎伴肺栓塞的认识,尽早识别,改善患者的生存质量。Neuropsychiatric symptoms such as seizures,cognitive declines,emotional and behavior changes are common,however,pulmonary embolism is rare in patients with paraneoplastic autoimmune encephalitis.Paraneoplastic autoimmune encephalitis with co-existence of multiple anti-neuronal antibodies is complex,and may have a poor prognosis.A case with paraneoplastic autoimmune encephalitis with co-existence of multiple anti-neuronal antibodies who was combined with pulmonary embolism was reported in this article.The features of this case were described in detail and the related literatures were reviewed to improve understanding of the comorbidities of paraneoplastic autoimmune encephalitis.

关 键 词：神经系统自身免疫疾病 脑炎 自身抗体 肺栓塞 

分 类 号：R742.9[医药卫生—神经病学与精神病学] R563.5[医药卫生—临床医学]