A Bioinspired Strategy Toward UV Absorption Enhancement of Melaninlike Polymers for Sun Protection  

作　　者：Zhen Yang Jianhua Zhang Huijie Liu Junfei Hu Xianheng Wang Wanjie Bai Wei Zhang Ye Yang Zhipeng Gu Yiwen Li 

机构地区：[1]State Key Laboratory of Polymer Materials Engineering,College of Polymer Science and Engineering,Sichuan University,Chengdu 610065 [2]State Key Laboratory of Physical Chemistry of Solid Surfaces,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen,Fujian 361005 [3]Laboratory for Biomaterials and Drug Delivery,The Department of Anesthesiology,Critical Care and Pain Medicine,Boston Children’s Hospital,Harvard Medical School,Boston,Massachusetts 02115

出　　处：《CCS Chemistry》2023年第10期2389-2402,共14页中国化学会会刊（英文）

基　　金：supported by National Natural Science Foundation of China(grant nos.52225311 and 21975167)and the Fundamental Research Funds for Central Universities.

摘　　要：Due to the complexity of the structure within melanin and synthetic polymers(i.e.,polydopamine,PDA),it is a challenge to regulate the ultraviolet(UV)absorption.In nature,melanocytes can biosynthesize more pheomelanins than eumelanins via protein and gene overexpression for photoprotection when the UV irradiation is enhanced.During this biosynthetic pathway,L-cystine,transported by xCT gene,can be involved to form a new monomer structure incorporating a benzothiazole group,finally resulting in the formation of UV absorption-enhanced pheomelanin.Inspired by this,we have proposed a facile strategy to regulate the UV absorption of PDA by introducing the benzimidazole(BI)unit through the thiol-Michael addition reaction during the polymerization process.It was further found that the introduction of BI units not only significantly increased the content of chromophores and auxochromes,but also effectively restricted the red-shift of the absorption spectrum via interrupting the conjugated microstructure within PDA,both of which contribute to UV absorption enhancement.These UV absorption-enhanced PDA nanoparticles could be used to fabricate bio-inspired sunscreens for efficient sun protection.This work will provide a facile strategy to regulate UV absorption of melanin-like materials and open new horizons for the design and construction of bioinspired sunscreens.

关 键 词：MELANIN sun protection POLYDOPAMINE UV absorption 

分 类 号：O62[理学—有机化学]