FGF-2及miR-215对早期胃癌患者经内镜黏膜下剥离术后复发的预测价值分析  

Analysis of the predictive value of FGF-2 and miR-215 for recurrence after endoscopic submucosal dissection in early gastric cancer patients

作　　者：徐毅[1] Xu Yi(Gastrointestinal surgery Department,The First People’s Hospital of Nanyang,Nanyang 473010,Henan,China)

机构地区：[1]南阳市第一人民医院胃肠外科,河南南阳473010

出　　处：《青岛医药卫生》2023年第5期321-325,共5页Qingdao Medical Journal

摘　　要：目的探讨成纤维细胞生长因子2(FGF-2)及miR-215对早期胃癌的诊断价值,并分析两者对患者经内镜黏膜下剥离术后复发的预测价值。方法2018年1月到2021年1月,选取我院收治的90例早期胃癌患者,将其分为观察组,另选取同期90例经病理活检确定为正常胃粘膜的志愿者,将其分为对照组。对比两组受检者FGF-2及miR-215表达水平,并建立受试者工作特征(ROC)曲线,分析FGF-2及miR-215对早期胃癌的诊断效能。90例早期胃癌患者均经内镜黏膜下剥离术治疗。术后对患者进行随访依照是否复发情况判定为复发组(n=20)和非复发组(n=70)两个亚组,对比两组患者一般临床情况,并应用logistic回归分析分析FGF-2及miR-215对早期胃癌患者经内镜黏膜下剥离术后复发的预测价值。结果观察组患者胃黏膜组织FGF-2阳性率、表达水平,miR-215阳性率、表达水平明显高于对照组(P<0.05);FGF-2对早期胃癌的诊断效能明显高于miR-215(P<0.05),其中FGF-2诊断早期胃癌的曲线下面积为0.852,最佳诊断界限值为1.11,miR-215曲线下面积为0.735,最佳诊断界限值为0.86;复发组与非复发组患者浸润深度、组织分化程度、FGF-2及miR-215水平对比差异显著(P<0.05);logistic回归分析结果表明:FGF-2及miR-215为胃癌患者预后的独立影响因素(P<0.05)。结论FGF-2及miR-215对于早期胃癌的诊断价值较高,且FGF-2、miR-215水平升高为早期胃癌经内镜黏膜下剥离术后复发的独立预测因素。Objective To explore the diagnostic value of fibroblast growth factor 2(FGF-2)and miR-215 in early gastric cancer,and to analyze their predictive value for recurrence after endoscopic submucosal dissection in patients.Method 90 early gastric cancer patients admitted to our hospital from January 2018 to January 2021 were selected as the study subjects and divided into an observation group.In addition,90 volunteers who were confirmed as normal gastric mucosa through pathological biopsy during the same period were selected and divided into a control group.Compare the expression levels of FGF-2 and miR-215 between two groups of subjects,and establish a receiver operating characteristic(ROC)curve to analyze the diagnostic efficacy of FGF-2 and miR-215 in early gastric cancer.90 patients with early gastric cancer were treated with endoscopic submucosal dissection.After surgery,patients were followed up and divided into two subgroups based on their recurrence status:the recurrent group(n=20)and the non recurrent group(n=70).The general clinical conditions of the two groups of patients were compared,and logistic regression analysis was used to analyze the predictive value of FGF-2 and miR-215 for recurrence in early gastric cancer patients after endoscopic submucosal dissection.Results The positive rate and expression level of FGF-2 in the gastric mucosa of the observation group were significantly higher than those of the control group,and the positive rate and expression level of miR-215 were significantly lower than those of the control group(P<0.05);The diagnostic efficiency of FGF-2 for early gastric cancer is significantly higher than that of miR-215(P<0.05).The area under the curve of FGF-2 for early gastric cancer diagnosis is 0.852,with an optimal diagnostic threshold of 1.11,an area under the curve of miR-215 is 0.735,and an optimal diagnostic threshold of 0.86;There was a significant difference in infiltration depth,tissue differentiation,FGF-2 and miR-215 levels between the recurrent and non recurrent groups(P

关 键 词：成纤维细胞生长因子2 miR-215 早期胃癌 内镜黏膜下剥离术 复发 预测价值 

分 类 号：R735.2[医药卫生—肿瘤]