血浆基质骨块用于牙槽嵴水平向骨增量的疗效观察  

Observation on the effect of plasmatrix bone block applied on alveolar horizontal bone augmentation

作　　者：李永军 余诗敏 张晓欣[1] 魏焱 曾浩 Li Yongjun;Yu Shimin;Zhang Xiaoxin;Wei Yan;Zeng Hao(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,School&Hospital of Stomatology,Wuhan University,Wuhan 430079,China)

机构地区：[1]武汉大学口腔医(学)院口颌系统重建与再生全国重点实验室口腔生物医学教育部重点实验室,口腔医学湖北省重点实验室,武汉430079

出　　处：《中华口腔医学杂志》2023年第10期1062-1066,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金(82101019)。

摘　　要：通过回顾系列病例性评估血浆基质骨块在牙槽嵴水平向骨增量中的应用效果。纳入2021年1月至2022年4月于武汉大众口腔医院种植科行牙槽嵴水平向骨增量的患者资料共25例,采用自体骨屑、脱蛋白牛骨基质和血浆基质制作血浆基质骨块,结合可吸收胶原膜和血浆基质膜进行引导性骨再生术。术前及术后6个月对患者锥形束CT数据进行三维重建,测量距牙槽嵴顶2及8 mm处骨宽度及牙槽骨体积。采用配对t检验比较相同测量项目两时间点间差异。结果显示,与术前[(5.5±3.4)mm]相比,术后6个月距牙槽嵴顶2 mm处骨宽度[(9.5±2.5)mm]显著增加(t=3.40,P<0.001);距牙槽嵴顶8 mm处骨宽度术前与术后6个月差异无统计学意义(t=3.13,P=0.050)。对于牙槽骨体积,术前距牙槽嵴顶2和8 mm处牙槽骨体积分别为(5114±3883)和(3329±2874)mm 3,术后6个月后分别显著增加至(5999±4318)和(4042±3260)mm 3(t=5.69,P<0.001;t=5.69,P<0.001)。证实在引导性骨再生术中采用血浆基质骨块+可吸收胶原膜+血浆基质膜进行水平向骨增量具有较好的治疗效果。A retrospective case series was used to evaluate the effect of plasmatrix bone blocks on bone augmentation at the level of the alveolar ridge.From January 2021 to April 2022,a total of 25 patients who underwent horizontal alveolar ridge level bone augmentation in the Department of Implantology,Wuhan Dazhong Stomatological Hospital were included.Autologous bone chips,deproteinized bovine bone matrix and plasma matrix were used to make plasma matrix bone blocks,combined with absorbable collagen membrane and plasma matrix membrane for guided bone regeneration.Three-dimensional reconstruction was performed on the cone beam CT data before operation and 6 months after operation,and the bone width and alveolar bone volume at 2 and 8 mm from the alveolar crest were measured.The paired t test was used to compare the differences between two time points of the same measurement item.The results showed that compared with preoperative[(5.5±3.4)mm]bone width,the bone width[(9.5±2.5)mm]at 2 mm from the alveolar crest was significantly increased at 6 months after operation(t=3.40,P˂0.001);there was no significant difference in the bone width at the level of 8 mm from the alveolar crest between pre-and 6 months post-operation(t=3.13,P=0.050).The volumes of alveolar bone at 2 and 8 mm from the alveolar crest were(5114±3883)and(3329±2874)mm3 before operation,respectively,and these increased significantly to(5999±4318)and(4042±3260)mm3(t=5.69,P˂0.001;t=5.689,P˂0.001)6 month post-operation.The results from this study has shown that the use of plasmatrix bone blocks+absorbable collagen membrane+plasma matrix membrane for horizontal bone augmentation in guided bone regeneration has a promising bone augmentation outcome.

关 键 词：牙种植 牙槽骨质丢失 血浆 血浆基质骨块 引导性骨再生术 

分 类 号：R783.6[医药卫生—口腔医学]