血小板抑菌作用的研究进展  

Research progress of platelet bacteriostatic effects

作　　者：王文华 邢莉莉 马婷[2] 杨江存[2] 魏绪仓[3] WANG Wenhua;XING Lili;MA Ting;YANG Jiangcun;WEI Xucang(Xi'an Medical University,Shaanxi Provincial People's Hospital,Xi'an 710068,China;Department of Blood Transfusion,Shaanxi Provincial People's Hospital,Xi'an 710068,China;Department of Hematology Laboratory,Shaanxi Provincial People's Hospital,Xi'an 710068,China)

机构地区：[1]西安医学院,陕西西安710068 [2]陕西省人民医院输血科,陕西西安710068 [3]陕西省人民医院血液病研究室,陕西西安710068

出　　处：《细胞与分子免疫学杂志》2023年第9期857-862,共6页Chinese Journal of Cellular and Molecular Immunology

基　　金：陕西省人民医院领军人才项目(2021LJ-14)。

摘　　要：血小板不仅具有止凝血功能,还可以通过膜受体直接或间接识别病原微生物及其产生的信号捕获和消灭病原菌,也可以通过释放血小板内颗粒物质、细胞因子和趋化因子与机体免疫系统各组成部分协作,发挥吞噬病原体、释放抗菌蛋白与趋化因子和激活与增强白细胞等其他专职抗炎细胞的杀菌作用。但血小板的抑菌成分及抑菌机制尚不明确,应关注血小板的免疫机制及抑菌效应。Platelets not only have hemostatic function,but can also directly or indirectly recognize pathogenic microorganisms and the signals they produce to capture and destroy them through membrane receptors.They can collaborate with various components of the body's immune system by releasing of intraplatelet particulate matter,cytokines and chemokines to perform bactericidal functions.And it can also play a bactericidal role by swallowing pathogens,releasing antimicrobial proteins and chemokines and activating and enhancing other specialized anti-inflammatory cells bactericidal effect,such as leukocytes and so on.However,the bacteriostatic composition and bacteriostatic mechanism of platelets remain unclear,so attention should be paid to the immune mechanism and bacteriostatic effect of platelets.

关 键 词：血小板 抑菌 趋化因子 抗菌肽 综述 

分 类 号：R331.143[医药卫生—人体生理学] G353.11[医药卫生—基础医学]