三种比例CGF与异种骨Bio-Oss联合应用于重度牙周炎位点保存的疗效评价  

Evaluation of three proportions of CGF combined with heterogeneous bone Bio-Oss used for alveolar ridge preservation of severely periodontitis-affected tooth sites

作　　者：王安琪[1,2] 汪涌[1,2,3] WANG An-qi;WANG Yong(Hefei Clinical School of Stomatology,Anhui Medical University,Anhui Hefei 230001,China;The Fifth Clinical Medical School of Anhui Medical University,Anhui Hefei 230001,China;Hefei Stomatological Hospital,Anhui Hefei 230001,China)

机构地区：[1]安徽医科大学合肥口腔临床学院,安徽合肥230001 [2]安徽医科大学第五临床医学院,安徽合肥230001 [3]合肥市口腔医院,安徽合肥230001

出　　处：《临床口腔医学杂志》2023年第10期606-610,共5页Journal of Clinical Stomatology

基　　金：2022年合肥市卫生健康应用医学研究项目(Hwk2022zc050);合肥市第七周期临床重点专科建设项目(合卫医秘[2023]72号)。

摘　　要：目的:通过影像学和组织学比较3种比例的浓缩生长因子(concentrated growth factors,CGF)与Bio-Oss骨粉混合物应用于重度牙周炎患牙位点保存术中的成骨效果。方法:将30颗患牙随机分为3组,调整CGF凝胶碎片的质量使CGF:Bio-Oss骨粉=1:1、1:2、2:1,分别对应A、B、C组。并拟合CBCT模型测量分析,种植术中取骨组织样本进行组织学分析。结果:术后6个月,C组颊侧垂直骨高度的增量(1.97±0.75 mm)均大于其余组,且与B组(0.92±1.01 mm)有统计学差异;C组牙槽骨体积的增量(339.77±101.94 mm^(3)),与另2组差异均有统计学意义。C组组织学图像显示大量新生骨和分布均匀的骨细胞,骨小梁排列紧密,骨成熟度高。结论:CGF与Bio-Oss骨粉以2:1的比例应用于重度牙周炎患牙位点保存术成骨效果相对更佳。Objective:The efficacy of applying three different ratios of concentrated growth factors(CGF)and Bio-Oss mixture in alveolar ridge preservation(ARP)of severely periodontitis-affected tooth sites was compared through radiographic and histological examination.Methods:Thirty affected teeth were randomly divided into three groups.The mass of CGF gel fragments was adjusted to achieve CGF:Bio-Oss ratios of 1:1,1:2,and 2:1,corresponding to group A,B and C,respectively.Measured and analyzed the fitted CBCT models.Bone tissue samples were taken during implantation.Results:Six months after operation,the increment of buccal vertical bone height in group C(1.97±0.75 mm)was greater than that in other groups,and there was a statistical difference between group C and group B(0.92±1.01 mm).The increment of alveolar bone volume in group C(339.77±101.94 mm^(3))was significantly different from that in the other two groups.The histology of group C showed a large number of new bones and evenly distributed bone cells,the bone trabeculae were closely arranged,and the bone maturity was high.Conclusion:The combination of CGF and Bio-Oss in 2:1 ratio is relatively better for ARP in severely periodontitis-affected teeth.

关 键 词：浓缩生长因子 混合比例 重度牙周炎 位点保存术 

分 类 号：R781.4[医药卫生—口腔医学]