Intricacies of TGF-βsignaling in Treg and Th17 cell biology  

作　　者：Junying Wang Xingqi Zhao Yisong Y.Wan 

机构地区：[1]Lineberger Comprehensive Cancer Center,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599,USA [2]Department of Microbiology and Immunology,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599,USA

出　　处：《Cellular & Molecular Immunology》2023年第9期1002-1022,共21页中国免疫学杂志（英文版）

基　　金：This work was supported by the NIH(R01 AI160774,R01 AI123193,and R56 AG071256);the National Multiple Sclerosis Society(RG-1802-30483 to YYW);The figures were created using BioRender.com.

摘　　要：Balanced immunity is pivotal for health and homeostasis.CD4+helper T(Th)cells are central to the balance between immune tolerance and immune rejection.Th cells adopt distinct functions to maintain tolerance and clear pathogens.Dysregulation of Th cell function often leads to maladies,including autoimmunity,inflammatory disease,cancer,and infection.Regulatory T(Treg)and Th17 cells are critical Th cell types involved in immune tolerance,homeostasis,pathogenicity,and pathogen clearance.It is therefore critical to understand how Treg and Th17 cells are regulated in health and disease.Cytokines are instrumental in directing Treg and Th17 cell function.The evolutionarily conserved TGF-β(transforming growth factor-β)cytokine superfamily is of particular interest because it is central to the biology of both Treg cells that are predominantly immunosuppressive and Th17 cells that can be proinflammatory,pathogenic,and immune regulatory.How TGF-βsuperfamily members and their intricate signaling pathways regulate Treg and Th17 cell function is a question that has been intensely investigated for two decades.Here,we introduce the fundamental biology of TGF-βsuperfamily signaling,Treg cells,and Th17 cells and discuss in detail how the TGF-βsuperfamily contributes to Treg and Th17 cell biology through complex yet ordered and cooperative signaling networks.

关 键 词：TGF-BETA regulatory T cell Th17 cell TREG 

分 类 号：R392[医药卫生—免疫学]