TGF-BETA

作品数：25被引量：83H指数：5
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相关作者：陈亮王晨辉魏传宇李文龙方迪峰更多>>
相关机构：复旦大学华中科技大学中国疾病预防控制中心圣诺制药公司更多>>
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Effect of atractylenolide Ⅲ on zearalenone-induced Snail1-mediated epithelial–mesenchymal transition in porcine intestinal epithelium
《Journal of Animal Science and Biotechnology》2024年第5期2081-2092,共12页Na Yeon Kim Myoung Ok Kim Sangsu Shin Woo‑Sung Kwon Bomi Kim Joon Yeop Lee Sang In Lee 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2022R1I1A3070740)。
Background The intestinal epithelium performs essential physiological functions,such as nutrient absorption,and acts as a barrier to prevent the entry of harmful substances.Mycotoxins are prevalent contaminants found ...
关键词：Atractylenolide III Epithelial–mesenchymal transition IPEC-J2 cells SNAIL TGF-beta signaling ZEARALENONE 
Intricacies of TGF-βsignaling in Treg and Th17 cell biology被引量：28
《Cellular & Molecular Immunology》2023年第9期1002-1022,共21页Junying Wang Xingqi Zhao Yisong Y.Wan 
This work was supported by the NIH(R01 AI160774,R01 AI123193,and R56 AG071256);the National Multiple Sclerosis Society(RG-1802-30483 to YYW);The figures were created using BioRender.com.
Balanced immunity is pivotal for health and homeostasis.CD4+helper T(Th)cells are central to the balance between immune tolerance and immune rejection.Th cells adopt distinct functions to maintain tolerance and clear ...
关键词：TGF-BETA regulatory T cell Th17 cell TREG 
Nano-Sustained CO-Releasing Molecules Alleviates Cyclosporin-A-Induced Nephrotoxicity and Renal Fibrosis by Inhibiting NLRP3 Inflammasome-Mediated TGF-β/Smad Signaling Pathway
《Journal of Clinical and Nursing Research》2023年第3期149-156,共8页Juan Ji Zhaoyu Bi Ling Tian Qian Zhang Shu-fen Hou Song Li 
Health Commission of Hebei Province Chuanxiong:Extract Improves Inflammatory Response in Rats with Pyelonephritis through IL-6/STAT3 Signaling Pathway(Project number:20231486)。
Objective:To investigate the effect nano-sustained CO-releasing molecules on cyclosporin-A(CsA)-induced nephrotoxicity by inhibiting the NLRP3 inflammasome-mediated TGF-β/Smad signaling pathway.Methods:3×105 cell/mL...
关键词：NLRP3 TGF-BETA Smad Renal fibrosis 
TGF-BETA信号通路介导的眼组织纤维化在眼病发生发展中作用的研究进展
《眼科新进展》2023年第4期327-331,共5页郝佳文 张瑞雪 彭媛 毕宏生 郭大东 
国家重点研发计划项目(编号:2021YFC2702103);山东省重点研发计划项目(2019GSF108252)。
眼科疾病的发生发展与眼组织的异常发育和功能障碍有关,其中相关信号通路的异常活化可使眼组织纤维化进而使其生理功能发生障碍,在眼病的发生和发展过程中发挥重要作用。转化生长因子β(TGF-β)信号通路广泛存在于各类细胞中,可参与细...
关键词：TGF-Β信号通路 纤维化 青光眼 视网膜疾病 晶状体疾病 
Flavonoid rich extract of Trigonella foenum-graecum leaves ameliorate liver fibrosis
《Food Bioscience》2022年第6期444-455,共12页Faiza Shams Ayesha Azeem Ammara Shams Abdul Tawab Sidra Rehman Somayya Tariq Noreen Latief Bushra Ijaz 
the Higher Education Commission Pakistan for providing a research grant(NRPU-8719)to conduct the research.
Liver fibrosis is a leading cause of mortality and morbidity globally.For decades,plant secondary metabolites such as flavonoids and saponins have attained much consideration due to their safer therapeutic potential a...
关键词：Liver fibrosis FLAVONOIDS Trigonella foenum-Graecum Inflammation FENUGREEK TGF-BETA 
探索黄芪,南、北沙参治疗尿路上皮癌的潜在靶点及作用机制
《大医生》2020年第10期8-11,共4页郑新龙 郑素雅 林根 
目的探索研究黄芪-南沙参-北沙参(HNB)扶正抗癌中药治疗尿路上皮癌(UC)患者可能的潜在分子机制。方法收集HNB的活性化合物并确定其靶标。分析免疫治疗尿路上皮癌细胞有效和无效的差异表达基因,获得UC免疫疗效相关靶标,构建蛋白互作网络(...
关键词：PD-L1 免疫激活 TGF-BETA 扶正中药 
SMAD7 and SERPINE1 as novel dynamic network biomarkers detect and regulate the tipping point of TGF-beta induced EMT被引量：6
《Science Bulletin》2020年第10期842-853,M0004,共13页Zhonglin Jiang Lina Lu Yuwei Liu Si Zhang Shuxian Li Guanyu Wang Peng Wang Luonan Chen 
supported by the National Key Research and Development Program of China (2017YFA0505500);the National Natural Science Foundation of China (31930022, 31771476, 61773196);Shanghai Municipal Science and Technology Major Project (2017SHZDZX01);Key Project of Zhangjiang National Innovation Demonstration Zone Special Development Fund (ZJ2018ZD-013);Ministry of Science and Technology Project (2017YFC0907505);Guangdong Provincial Key Laboratory Funds (2017B030301018, 2019B030301001);Shenzhen Research Funds (JCYJ20170307104535585, ZDSYS20140509142721429);Shenzhen Peacock Plan (KQTD2016053117035204)
Epithelial–mesenchymal transition(EMT) is a complex nonlinear biological process that plays essential roles in fundamental biological processes such as embryogenesis, wounding healing, tissue regeneration,and cancer ...
关键词：Dynamic network biomarker Tipping point Epithelial–mesenchymal transition BISTABILITY Quantitative real-time PCR 
桂皮醛通过TGF-beta信号通路调控结直肠癌细胞侵袭和转移研究被引量：5
《现代消化及介入诊疗》2020年第3期340-344,349,共6页瞿晓媛 邰文琳 徐益恒 李劲榆 
云南省医学科学技术研究基金项目(A2017186)。
目的研究桂皮醛通过转化生长因子-β(TGF-β)信号通路调控结直肠癌细胞侵袭和转移的机制。方法用不同浓度桂皮醛处理人结肠癌SW480细胞,观察SW480细胞增殖活性、细胞凋亡、侵袭、转移能力及凋亡、上皮间质转化(EMT)、TGF-β/Smad3信号...
关键词：结直肠癌 桂皮醛 转化生长因子-Β 侵袭 转移 
Antitumor immunity of low-dose cyclophosphamide:changes in T cells and cytokines TGF-beta and IL-10 in mice with colon-cancer liver metastasis被引量：2
《Gastroenterology Report》2020年第1期56-65,I0002,共11页Xiao-Ming Huang Nan-Rong Zhang Xu-Tao Lin Cai-Yan Zhu Yi-Feng Zou Xiao-Jian Wu Xiao-Sheng He Xiao-Wen He Yun-Le Wan Ping Lan 
This work was supported by National Key Clinical Discipline,the Fundamental Research Funds for the young teacher training program of Sun Yat-sen University[grant number 18ykpy02];Medical Scientific Research Foundation of Guangdong Province of China[grant number A2016198];‘5010 Clinical Research Programme’of Sun Yat-sen University[grant number 2010012].
Background:The tumor immune microenvironment is one of the most important prognostic factors in liver metastasis from colorectal cancer.Low-dose cyclophosphamide(CTX)is widely believed to be involved in the modulation...
关键词：colon cancer liver metastasis CYCLOPHOSPHAMIDE immune microenvironment 
Protective effects of Foeniculum vulgare root bark extract against carbon tetrachloride-induced hepatic fibrosis in mice被引量：10
《World Journal of Gastroenterology》2017年第31期5722-5731,共10页cai zhang xing tian ke zhang guo-yu li hang-yu wang jin-hui wang 
Supported by National Key Technology R&D Program,No.2012BAI30B02
AIM To investigate the protective effects of Foeniculum vulgare root bark (FVRB), a traditional Uyghur medicine, against carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice. METHODS Mice were randomly divided...
关键词：Hepatic fibrosis Foeniculum vulgare root bark HISTOPATHOLOGY Carbon tetrachloride TGF-beta 1 
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