Mass cytometry uncovers a distinct peripheral immune profile and upregulated CD38 expression in patients with hidradenitis suppurativa  

作　　者：Peter Dimitrion Iltefat Hamzavi Congcong Yin Jugmohit Toor Kalpana Subedi Namir Khalasawi Angela Miller Richard Huggins Indra Adrianto Jesse Veenstra Gautham Vellaichamy Aakash Hans Steven Daveluy Mohammad Athar Wilson Liao Henry Lim David Ozog Li Zhou Qing-Sheng Mi 

机构地区：[1]Center for Cutaneous Biology and Immunology Research,Department of Dermatology,Henry Ford Health System,Detroit,MI,48202,USA [2]Immunology Research Program,Henry Ford Cancer Institute,Henry Ford Health System,Detroit,MI,48202,USA [3]Cancer Biology Graduate Program,School of Medicine,Wayne State University,Detroit,MI,48202,USA [4]Center for Bioinformatics,Department of Public Health Sciences,Henry Ford Health System,Detroit,MI,48202,USA [5]Department of Dermatology,Wayne State University School of Medicine,Detroit,MI,48202,USA [6]University of Alabama at Birmingham(UAB)Research Center of Excellence in Arsenicals,Department of Dermatology,University of Alabama at Birmingham,Birmingham,AL,USA [7]Department of Dermatology,University of California San Francisco,San Francisco,CA,USA [8]Department of Biochemistry,Microbiology,and Immunology,School of Medicine,Wayne State University,Detroit,MI,48202,USA

出　　处：《Cellular & Molecular Immunology》2023年第8期972-975,共4页中国免疫学杂志(英文版)

基　　金：funded by NIH/NIAMS(R01AR078688 to Q-SM and WL,R21AR079089 to Q-SM and IA);the Henry Ford Immunology Program(T71016 to Q-SM and T71017 to LZ).

摘　　要：Hidradenitis suppurativa(HS)is a chronic inflammatory skin disease with a worldwide prevalence of 0.3–4.0%,wherein abscesses and dermal sinus tracts form in intertriginous skin[1].HS remains poorly treated due to a lack of knowledge regarding its immunopathogenesis[2].

关 键 词：CD38 PATIENTS PATHOGENESIS 

分 类 号：R751[医药卫生—皮肤病学与性病学]