A histone tale that enCOMPASSes pausing:new insights into the functional repertoire of H3K4me3  

作　　者：Thomas K.Albert Kornelius Kerl 

机构地区：[1]Department of Pediatric Hematology and Oncology,University Children’s Hospital Muenster,Muenster,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第8期3555-3557,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the Kinderkrebshilfe Muenster,the Deutsche Krebshilfe,the Deutsche Kinderkrebsstiftung and the Deutsche Forschungsgemeinschaft to K.K.

摘　　要：A recently published study in Nature provides compelling evidence for the involvement of the histone H3K4me3 modification in regulating RNA polymerase II(Pol II)pause-release and elongation.1 The expansion of the functional repertoire of this active chromatin mark and the elucidation of the molecular mechanisms behind it represents a major advance for the field,not least because the epigenetic factors involved are linked to a wide range of human pathologies.The term epigenetics derives from the Greek prefix“epi”and describes an inheritable regulatory state that manifests itself beyond the mere genetic information encoded in the DNA.

关 键 词：INVOLVEMENT functional insight 

分 类 号：R392.2[医药卫生—免疫学]