Commanding the Commander:structure of a key protein machinery in endosomal trafficking  

作　　者：Xin Yong Chunzhuang Zhou Daniel D.Billadeau Da Jia 

机构地区：[1]Key Laboratory of Birth Defects and Related Diseases of Women and Children,Department of Paediatrics,West China Second University Hospital,State Key Laboratory of Biotherapy,Sichuan University,Chengdu 610041,China [2]Division of Oncology Research and Schulze Center for Novel Therapeutics,Mayo Clinic,Rochester,MN 55905,USA

出　　处：《Signal Transduction and Targeted Therapy》2023年第9期3877-3879,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by Natural Science Foundation of China(NSFC#32200559,#92254302);National Key Research and Development Program of China(2022YFA1105200);National Science Fund for Distinguished Young Scholars(#32125012);National Institutes of Health grant DK107733 to D.D.B.

摘　　要：In a recent study published in Cell1 and two bioRxiv pre-prints,2,3 three studies investigate the structure of the endosomal Commander complex through a combination of X-ray crystal-lography,cryogenic-electron microscopy(Cryo-EM),Alphafold predictions and extensive site-directed mutagenesis(Fig.1a),which sheds lights on the molecular characteristics of this evolutionarily-conserved protein machinery,and enables the mapping of mutations causing X-linked intellectual disability(XILD)and Ritscher-Schinzel syndrome(RSS).When proteins enter the endosomal network,they are either transported to lysosome for degradation,or recycled to the plasma membrane or the trans-Golgi network for reuse.Multiple protein machineries are essential for the process,including Retromer,Commander,and several members of the sorting nexin(SNX)family.Commander genes are highly conserved in metazoa and can be found in almost all tissues and cells.

关 键 词：COMMANDER COMMAND SORTING 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]