Lactic control of tumor growth:a new role for an old metabolite  

作　　者：Carolina E.Hagberg 

机构地区：[1]Division of Cardiovascular Medicine,Department of Medicine Solna,Karolinska Institutet,Stockholm,Sweden and 2 Center for Molecular Medicine,Karolinska Institutet,Stockholm,Sweden

出　　处：《Signal Transduction and Targeted Therapy》2023年第9期3890-3891,共2页信号转导与靶向治疗(英文)

摘　　要：In a recent study published in Nature,Liu and co-workers show that high lactate production by tumor cells promotes premature mitotic escape and further cell proliferation by facilitating the binding of Ubiquitin Conjugating Enzyme E2 C(UBE2C)to the anaphase promoting complex(APC/C).1 This is important as it suggests cancer metabolism not only to be a consequence of tumor growth,but also one of its drivers.Since its initial discovery over 200 years ago,lactate has sustained the interest of a wide range of research fields due to its significance as energy fuel,redox buffer and signaling molecule.2 High quantities of lactate are produced through glycolysis in muscle during exercise,through bacterial lactic acid fermentation,and perhaps most famously,by rapidly growing tumor cells.

关 键 词：METABOLISM SUSTAINED CONSEQUENCE 

分 类 号：R730[医药卫生—肿瘤]