Sebaceous gland reprogramming with a single gene, PPARG, and small molecules  

作　　者：Yiqiong Liu Shuaifei Ji Huanhuan Gao Huating Chen Jiangbing Xiang Shaoyuan Cui Christos CZouboulis Aizhen Cai Xiaobing Fu Xiaoyan Sun 

机构地区：[1]Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center,PLA General Hospital and PLA Medical College,PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury,Repair,and Regeneration,Research Unit of Trauma Care,Tissue Repair and Regeneration,Chinese Academy of Medical Sciences,2019RU051,100048 Beijing,P.R.China [2]Department of Nephrology,The First Medical Center,Chinese PLA General Hospital,State Key Laboratory of Kidney Diseases,100048 Beijing,China [3]Departments of Dermatology,Venereology,Allergology,and Immunology,Staedtisches Klinikum Dessau,Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg,Dessau,Germany [4]Institute of General Surgery,Department of General Surgery,the 1st Medical Center,PLA General Hospital,28 Fu Xing Road,100853 Beijing,P.R.China

出　　处：《Signal Transduction and Targeted Therapy》2023年第9期3913-3916,共4页信号转导与靶向治疗（英文）

基　　金：This work was supported in part by the National Natural Science Foundation of China(92268206,81830064);the CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-059);the Military Medical Research Projects(145AKJ260015000X,2022-JCJQ-ZB-09600,2020-JCJQ-ZD-256-021);the Military Medical Research and Development Projects(AWS17J005,2019-126);the Specific Research Fund of The Innovation Platform for Academicians of Hainan Province(YSPTZX202317).

摘　　要：Dear Editor,Sebaceous glands(SG)contribute to 90%of the skin surface lipid production and play critical roles in regulating proper skin functions including epidermal barrier maintenance,dermal immune responses,and global body anti-microbial activities.1 Reduced sebaceous lipid has been implicated in diverse skin diseases,including scarring alopecia,inflammation,chronic itch,as well as premature aging of the skin.2 Especially,scar repair after deep burns or large-scale skin defect often leads to irreversible loss of appendages.Due to lacking SG,the regenerated tissues cannot fully recapitulate the structural and functional integrity of normal skin.Therefore,generation of expandable SG cells with developmental and lipid-producing potentials represents a promising approach for treating diseased,damaged,or aged skin with better quality of life.Recently,direct cellular reprogramming has been widely used for obtaining difficult-to-maintain human cells by cell type-specific transcription factors(TFs).

关 键 词：PROGRAMMING MAINTAIN IRREVERSIBLE 

分 类 号：R751[医药卫生—皮肤病学与性病学]