玻璃体腔不同抗VEGF药物治疗老年黄斑变性的疗效及对黄斑中心凹视网膜厚度的影响  

Curative effect of intravitreal injection with different anti-VEGF drugs on age-related macular degeneration and their influences on central retinal thickness

作　　者：苏小波 侯红超 李岩 Su Xiaobo;Hou Hongchao;Li Yan(Henan Province Xiangcheng County Peoples Hospital Ophthalmology Henan,xuchagn 461700;Puri Eye Hospital,Zhengzhou Ophthalmology Henan,zhengzhou 450000)

机构地区：[1]河南省襄城县人民医院,河南许昌461700 [2]郑州市普瑞眼科医院,河南郑州450000

出　　处：《辽宁医学杂志》2023年第4期79-82,共4页Medical Journal of Liaoning

摘　　要：目的探讨玻璃体腔不同抗VEGF药物治疗老年黄斑变性的疗效及对黄斑中心凹视网膜厚度的影响。方法选取2018年2月-2020年2月在本院确诊的110例老年性黄斑变性患者,采用简单随机分组将患者分为观察组和对照组,每组各55例。对照组患者采用玻璃体腔注射雷珠单抗治疗,观察组采用康柏西普治疗,均持续治疗3个月。分别于治疗前后,分别在治疗前和治疗后1周、1个月、3个月对观察组和对照组患者采用标准视力表检测裸眼视力、采用光学相干断层扫描仪进行黄斑中心凹视网膜厚度检测。记录两组治疗期间的不良反应发生情况。结果观察组患者总有效率高于对照组总有效率,差异具有统计学意义(P<0.05)。治疗后1周、1个月、3个月观察组和对照组裸眼视力均高于治疗前(P<0.05),且观察组裸眼视力均低于对照组,差异具有统计学意义(P<0.05)。治疗后1周、1个月、3个月观察组和对照组裸眼视力均低于治疗前(P<0.05),且治疗后1周、1个月观察组黄斑中心凹视网膜厚度均高于对照组,差异具有统计学意义(P<0.05),治疗后3个月两组患者黄斑中心凹视网膜厚度差异无统计学意义(P>0.05)。两组患者治疗总并发症发生率差异无统计学意义(P>0.05)。结论康柏西普和雷珠单抗治疗老年黄斑变性疗效确切,但康柏西普在减少CNV渗漏方面优于雷珠单抗,而雷珠单抗在提高视力和改善黄斑中心凹厚度优于康柏西普。Objective To explore the curative effect of intravitreal injection with different anti-VEGF drugs on age-re-lated macular degeneration(AMD)and their influences on central retinal thickness.Methods A total of 110 patients with AMD confirmed in the hospital were enrolled between February 2018 and February 2020.They were divided into observation group and control group by simple random grouping method,55 cases in each group.The control group was treated with in-travitreal injection of ranibizumab,while observation group was treated with intravitreal injection of conbercept.All were con-tinuously treated for 3 months.Before treatment,at 1 week,1 month and 3 months after treatment,uncorrected visual acuity in both groups was tested by standard visual charts,and central retinal thickness was detected by optical coherence tomo-graphy.The occurrence of adverse reactions during treatment in both groups was recorded.Results The total response rate of observation group was higher than that of control group,the difference was statistically significant(P<0.05).The uncor-rected visual acuity of observation group and control group at 1 week,1 month and 3 months after treatment was higher than that before treatment(P<0.05),which was lower in observation group than control group,the difference was statistically significant(P<0.05).Compared with that before treatment,central retinal thickness in observation group was higher than that in control group at 1 week and 1 month after treatment(P<0.05).There was no significant difference in central retinal thickness betweem the two groups at 3 months after treatment(P>0.05).There was no significant difference in the overall incidence of complications between the two groups(P>0.05).Conclusion The curative effect of both conbercept and ranibizumab is significant on AMD.However,conbercept is superior to ranibizumab in reducing CNV leakage,while ranibi-zumab is superior to conbercept in improving visual acuity and central retinal thickness.

关 键 词：雷珠单抗 康柏西普 老年黄斑变性 

分 类 号：R774.5[医药卫生—眼科]