含载药微球动脉化疗栓塞术方案治疗化疗无效的非小细胞肺癌的临床效果  

Clinical efficacy of transcatheter hepatic arterial chemoembolization with drug-loaded microspheres in the treatment of non-small cell lung cancer with ineffective chemotherapy

作　　者：许玉华[1] 江强[1] 刘新兰 XU Yuhua;JIANG Qiang;LIU Xinan(Department of Interventional Vascular,Jiangxi Chest Hospital,Jiangxi Province,Nanchang 330006,China;Department of Surgery,Xinjian District Hospital of Traditional Chinese Medicine,Jiangxi Province,Nanchang 330100,China)

机构地区：[1]江西省胸科医院介入血管科,江西南昌330006 [2]江西省南昌市新建区中医院外科,江西南昌330100

出　　处：《中国当代医药》2023年第30期100-103,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(20204745)。

摘　　要：目的评价含载药微球动脉化疗栓塞术(TACE)方案治疗化疗无效的非小细胞肺癌(NSCLC)的临床效果。方法选取2019年4月至2021年4月江西省胸科医院收治的60例经化疗治疗无效的NSCLC患者作为研究对象,按照随机数字表法将其分为观察组(30例)与对照组(30例)。观察组采用含载药微球TACE方案治疗,对照组采用空白微球TACE方案治疗。比较两组患者临床疗效、癌胚抗原(CEA)、生活质量、无进展生存期(PFS)、总生存期(OS)及不良反应。结果观察组患者的治疗有效率(RR)、疾病控制率(DCR)均高于对照组,差异有统计学意义(P<0.05);治疗后,两组患者的CEA均低于本组治疗前,KPS评分均高于本组治疗前,且观察组患者的CEA低于对照组,KPS评分高于对照组,差异有统计学意义(P<0.05);观察组患者的PFS及OS均长于对照组,差异有统计学意义(P<0.05);两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论含载药微球TACE方案治疗化疗无效的NSCLC对疾病进展的控制能力优于空白微球,有利于提高RR、DCR及生活质量,降低CEA水平,延长PFS及OS,且不良反应并未增加。Objective To evaluate the clinical effect of transcatheter hepatic arterial chemoembolization(TACE)with drug-loaded microspheres in the treatment of non-small cell lung cancer(NSCLC)with ineffective chemotherapy.Methods A total of 60 patients with NSCLC with ineffective chemotherapy treatment in Jiangxi Chest Hospital from April 2019 to April 2021 were selected as the research objects,and they were divided into observation group(30 cases)and control group(30 cases)according to random number table method.The observation group was treated with TACE with drug-loaded mi-crospheres,and the control group was treated with TACE with blank microsphere.The clinical efficacy,carcinoembryonic antigen(CEA),quality of life,progression free survival(PFS),overall survival(OS)and adverse reactions were compared be-tween the two groups.Results The response rate(RR)and disease control rate(DCR)in observation group were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,the CEA of two groups were lower than those before treatment,the KPS scores were higher than those before treatment,and the CEA of observation group was lower than that of control group,the KPS score was higher than that of control group,the differences were statistically significant(P<0.05).PFS and OS in observation group were longer than those in control group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidences of adverse reactions between the two groups(P>0.05).Conclusion TACE with drug-loaded microspheres is better than blank microsphere in the control of disease progression in NSCLC patients with ineffective chemotherapy treatment.It is beneficial to improve RR,DCR and quality of life,reduce CEA level,prolong PFS and OS,and there is no increase in adverse reactions.

关 键 词：化疗无效的非小细胞肺癌 含载药微球动脉化疗栓塞术 空白微球动脉化疗栓塞术 癌胚抗原 总生存期 

分 类 号：R734.2[医药卫生—肿瘤]