全身炎性反应指数联合控制营养状况评分对结肠癌患者预后的预测价值  

Predictive value of SIRI combined with CONUT score in prognosis of patients with colon cancer

作　　者：徐敏 王彦舟 张华[2] XU Min;WANG Yanzhou;ZHANG Hua(Department of Gastroenterology,Wujin Hospital Affiliated to Jiangsu University,Changzhou 213000,China)

机构地区：[1]江苏大学附属武进医院徐州医科大学武进临床学院消化内科,江苏常州213000 [2]江苏大学附属武进医院徐州医科大学武进临床学院肿瘤科,江苏常州213000

出　　处：《陕西医学杂志》2023年第11期1558-1562,1566,共6页Shaanxi Medical Journal

基　　金：江苏省卫生和计划生育委员会医学科研项目(H20180086)。

摘　　要：目的:探讨全身炎性反应指数(SIRI)联合控制营养状况(CONUT)评分对结肠癌患者预后的预测价值。方法:选择结肠癌患者118例为结肠癌组,选择体检健康者75例为对照组。比较两组SIRI、CONUT评分。分析SIRI、CONUT评分与结肠癌患者临床病理特征的关系。采用Kaplan-Meier曲线和Cox回归分析SIRI、CONUT评分与结肠癌患者预后的关系。采用受试者工作特征(ROC)曲线分析SIRI和CONUT评分对结肠癌患者预后的预测价值。结果:结肠癌组SIRI、CONUT评分高于对照组(均P<0.05)。低分化、TNMⅢ-Ⅳ期、有神经侵犯的结肠癌患者SIRI、CONUT评分高于中高分化、TNMⅠ-Ⅱ期、无神经侵犯的结肠癌患者(均P<0.05)。高SIRI、高CONUT评分结肠癌患者无复发生存(RFS)、总生存(OS)率低于低SIRI、低CONUT评分结直癌患者(均P<0.05)。TNMⅢ-Ⅳ期、高SIRI、高CONUT评分是结肠癌患者预后的独立危险因素(均P<0.05)。SIRI联合CONUT评分预测结肠癌患者预后的曲线下面积高于两者单独预测(均P<0.05)。结论:结肠癌患者SIRI、CONUT评分升高,而高SIRI和CONUT评分与结肠癌高TNM分期、分化程度、神经侵犯以及低RFS、OS生存率有关,因此可作为预测结肠癌患者预后的标志物。Objective:To investigate the predictive value of Systemic Inflammatory Response Index(SIRI)combined with Controlling Nutritional Status(CONUT)score in the prognosis of patients with colon cancer.Methods:A total of 118 patients with colon cancer were selected as the colon cancer group,and 75 healthy people were selected as the control group.SIRI and CONUT score were compared between the two groups.The relationship between SIRI,CONUT score and clinicopathological characteristics of colon cancer patients was analyzed.Kaplan-Meier curve and Cox regression were used to analyze the relationship between SIRI,CONUT score and the prognosis of patients with colon cancer.ROC curve was used to analyze the predictive value of SIRI and CONUT score for the prognosis of patients with colon cancer.Results:The SIRI and CONUT score of the colon cancer group were higher than those of the control group(all P<0.05).The SIRI and CONUT score of colon cancer patients with low differentiation,TNMⅢ-Ⅳstage and nerve invasion were higher than those of colon cancer patients with moderately and high differentiation,TNMⅠ-Ⅱstage and no nerve invasion(all P<0.05).The recurrence-free survival(RFS)and overall survival(OS)of colon cancer patients with high SIRI and high CONUT score were lower than those of colorectal cancer patients with low SIRI and low CONUT score(all P<0.05).TNM stageⅢ-Ⅳ,high SIRI and high CONUT score were independent risk factors for the prognosis of colon cancer patients(all P<0.05).The AUC of SIRI combined with CONUT score for predicting the prognosis of colon cancer patients was higher than that of SIRI or CONUT score alone(all P<0.05).Conclusion:SIRI and CONUT score are increased in patients with colon cancer,and high SIRI and CONUT score are related to high TNM stage,differentiation,nerve invasion,low RFS and OS survival rates of colon cancer,so they can be used as markers to predict the prognosis of patients with colon cancer.

关 键 词：结肠癌 全身炎症反应指数 控制营养状况评分 无复发生存 总生存 预测价值 

分 类 号：R735.35[医药卫生—肿瘤]