香砂六君子汤联合瑞巴派特对胃溃疡疗效及胃黏膜蛋白的影响  

Effect of Xiangsha Liujunzi Decoction combined with rebamipide on efficacy of gastric ulcer and gastric mucosa protein

作　　者：李雪梅[1,2] 刘焰东 LI Xuemei;LIU Yandong(Guangzhou University of Traditional Chinese Medicine,Guangzhou,Guangdong,510470;the First Department of Internal Medicine,Baiyun Hospital of the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou,Guangdong,510470)

机构地区：[1]广州中医药大学,广东广州510470 [2]广州中医药大学第一附属医院白云医院内一科,广东广州510470

出　　处：《实用临床医药杂志》2023年第19期84-88,共5页Journal of Clinical Medicine in Practice

基　　金：广州市白云区2018年科技计划项目(2018-YL-010)。

摘　　要：目的 探讨香砂六君子汤联合瑞巴派特治疗脾胃不和型胃溃疡及对胃黏膜蛋白水平影响。方法 选取2022年1—12月收治的130例脾胃不和型胃溃疡患者为研究对象,按随机数字表法将其分为对照组与研究组,每组65例。对照组采用瑞巴派特治疗,研究组在对照组基础上予以香砂六君子汤治疗。2组患者均持续治疗6周。评估2组临床疗效及安全性。比较2组治疗前后中医证候评分及溃疡愈合情况。比较2组治疗前后胃泌素-17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及PGⅠ与PGⅡ的比值(PGⅠ/PGⅡ)。结果 研究组患者幽门螺杆菌根除率及治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,2组患者症状积分、溃疡愈合组织学观察评分以及G-17、PGⅠ、PGⅡ水平和PGⅠ/PGⅡ低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组头晕2例,对照组头晕1例,2组不良反应发生率比较,差异无统计学意义(P=0.559)。结论 香砂六君子汤联合瑞巴派特治疗脾胃不和型胃溃疡疗效及安全性均较高,可有效改善患者中医证候,调节胃黏膜蛋白水平,加速胃黏膜愈合。Objective To explore the effect of Xiangsha Liujunzi Decoction combined with re-bamipide in the treatment of gastric ulcer with disharmony between spleen and stomach type and its impact on the level of gastric mucosal protein.Methods A total of 130 gastric ulcer with disharmony between spleen and stomach type admitted from January to December 2022 were selected as study ob-jects,and were divided into control group and study group according to random number table method,with 65 cases in each group.Patients in the control group were treated with ribapet,and patients in the study group were treated with Xiangsha Liujunzi Decoction on the basis of the control group.Both groups were treated continuously for 6 weeks.The clinical efficacy and safety of the two groups were evaluated.The TCM syndrome score and ulcer healing before and after treatment in the two groups were compared.The levels of gastrin-17(G-17),pepsinogen I(PG I),pepsinogen I(PG I)and PG I-to-PG II ratio(PG I/PG I)in the two groups were compared before and after treatment.Results The Helicobacter pylori eradication rate and overall effective rate of patients in the study group was signifi-cantly higher than that in the control group(P<0.05).After treatment,the symptom score,histolog-ical observation score of ulcer healing,G-17 level,PG I level,PG II level and PG I/PG II in the two groups were significantly lower than those before treatment,and were significantly lower in the study group than those in the control group(P<0.05).Dizziness occurred in 2 cases in the study group and 1 case in the control group.There was no significant difference in the incidence of adverse reactions between the two groups(P=0.559).Conclusion Xiangsha Liujunzi Decoction combined with rebapide has high efficacy and safety in the treatment of gastric ulcer with disharmony between spleen and stomach type,which can effectively improve the TCM symptoms of patients,regulate the level of gastric mucosal protein,and accelerate the healing of gastric mucosa.

关 键 词：香砂六君子汤 瑞巴派特 脾胃不和型 胃溃疡 胃黏膜蛋白酶原 

分 类 号：R573.1[医药卫生—消化系统] R242[医药卫生—内科学]